1. Neuronal Signaling
  2. AChE
  3. Pseudocoptisine chloride

Pseudocoptisine chloride (Synonyms: Isocoptisine chloride)

Cat. No.: HY-N6894A Purity: 99.17%
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Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects.

For research use only. We do not sell to patients.

Pseudocoptisine chloride Chemical Structure

Pseudocoptisine chloride Chemical Structure

CAS No. : 30044-78-1

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Based on 1 publication(s) in Google Scholar

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Description

Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects[1][2].

In Vitro

Pseudocoptisine (0, 60, 90 μM; 1 hour) dose-dependently inhibited LPS-induced NO production in RAW264.7 cells[2].
Pseudocoptisine (30-90 μM; 1 hour; RAW264.7 cells) significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions[1].
Pseudocoptisine acetate reduces levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation in RAW 264.7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) are examined. Pseudocoptisine (2.0 mg/kg, p.o.) significantly reverses cognitive impairments in mice by passive avoidance test[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

355.77

Formula

C₁₉H₁₄ClNO₄

CAS No.
SMILES

C12=[N+](C=C3C(C=C4C(OCO4)=C3)=C2)CCC5=CC6=C(OCO6)C=C15.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Keywords:

PseudocoptisineIsocoptisineAChEAcetylcholinesteraseanti-inflammatoryanti-amnesticpro-inflammatorycytokinesRAW 264.7Inhibitorinhibitorinhibit

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Pseudocoptisine chloride
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