30044-78-1
Chemical Structure
Pseudocoptisine chloride
Synonym(s): Isocoptisine chloride
- CAS No.: 30044-78-1
- Formula:C19H14ClNO4
- Molecular Weight:355.77
IUPAC Name: 5,6-dihydro-[1,3]dioxolo[4',5':6,7]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinolin-7-ium chloride
InChIKey: QBOVLUUBUAZWIN-UHFFFAOYSA-M
SMILES: C12=[N+](C=C3C(C=C4C(OCO4)=C3)=C2)CCC5=CC6=C(OCO6)C=C15.[Cl-]
Biological Activity: Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects[1][2].
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Pseudocoptisine chloride | 98.76% | Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects. | ||||||||||||||||||||
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Similarity Score 0.93
HY-N6894Pseudocoptisine acetate -
Similarity Score 0.80
HY-N0736RCoptisine chloride (Standard) -
Similarity Score 0.80
HY-155229CBP/p300-IN-21 -
Similarity Score 0.79
HY-N0430Coptisine -
Similarity Score 0.75
HY-N0430ACoptisine Sulfate -
Similarity Score 0.72
HY-125850Berberrubine chloride -
Similarity Score 0.71
HY-18258Berberine chloride -
Similarity Score 0.70
HY-N0716Berberine -
Similarity Score 0.70
HY-17577Berberine chloride hydrate -
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References
- [1]. Hung TM, et al. Anti-amnestic activity of pseudocoptisine from Corydalis Tuber. Biol Pharm Bull. 2008;31(1):159-162. [Content Brief]
- [2]. Yun KJ, et al. Quaternary alkaloid, pseudocoptisine isolated from tubers of Corydalis turtschaninovi inhibits LPS-induced nitric oxide, PGE(2), and pro-inflammatory cytokines production via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage c [Content Brief]
