1. Stem Cell/Wnt
    Autophagy
  2. β-catenin
    Wnt
    Autophagy

Berberine chloride hydrate (Synonyms: Natural Yellow 18)

Cat. No.: HY-17577 Purity: 99.56%
Handling Instructions

Berberine has shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells; MAPK and Wnt/β-catenin pathways affected by Berberine.

For research use only. We do not sell to patients.

Berberine chloride hydrate Chemical Structure

Berberine chloride hydrate Chemical Structure

CAS No. : 141433-60-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 g USD 72 In-stock
Estimated Time of Arrival: December 31
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Other Forms of Berberine chloride hydrate:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Berberine has shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells; MAPK and Wnt/β-catenin pathways affected by Berberine. IC50 value: Target: Anticancer agent The plant-based alkaloid berberine has potential therapeutic applications for breast cancer, although a better understanding of the genes and cellular pathways regulated by this compound is needed to define the mechanism of its action in cancer treatment. In this review, the molecular targets of berberine in various cancers, particularly breast cancer, are discussed. Berberine was shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells. Some signaling pathways affected by berberine, including the MAP (mitogen-activated protein) kinase and Wnt/β-catenin pathways, are critical for reducing cellular migration and sensitivity to various growth factors [1]. Treatment with BBR(Berberine) in rats on the atherogenic diet reduced plasma total cholesterol and nonHDL cholesterol levels by 29%-33% and 31%-41%, respectively, with no significant differences being observed among the three doses [2]. Berberine induced both apoptotic and autophagic death of HepG2 cells, which was associated with a significant activation of AMPK and an increased expression of the inactive form of acetyl-CoA carboxylase (ACC) [3]. Berberine did not show major effects on viability of HEK-293 embryonic kidney and HCT116 colon carcinoma cells and was not toxic in concentrations up to 20 μM. Berberine inhibited β-catenin transcriptional activity and attenuated anchorage-independent growth. As a result of berberine treatment, cellular levels of active β-catenin were reduced concomitant with an increase in the expression of E-cadherin [4].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 3.9 mg/mL

*"≥" means soluble, but saturation unknown.

References
Formula

C₂₀H₁₈NO₄.Cl.xH₂O

CAS No.

141433-60-5

SMILES

COC1=C(OC)C2=C[N+]3=C(C(C(CC3)=C4)=CC5=C4OCO5)C=C2C=C1.[Cl-].[x H2O]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.56%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Berberine chloride hydrate
Cat. No.:
HY-17577
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Berberine chloride hydrate

Cat. No.: HY-17577