1. Neuronal Signaling
  2. Monoamine Oxidase
    AChE
  3. Ladostigil hemitartrate

Ladostigil hemitartrate (Synonyms: TV-3326 hemitartrate)

Cat. No.: HY-10400
Handling Instructions

Ladostigil (TV-3326) hemitartrate is a dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease.

For research use only. We do not sell to patients.

Ladostigil hemitartrate Chemical Structure

Ladostigil hemitartrate Chemical Structure

CAS No. : 209394-46-7

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5 mg USD 430 In-stock
Estimated Time of Arrival: December 31
10 mg USD 690 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1380 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Ladostigil (TV-3326) hemitartrate is a dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease[1][2].

IC50 & Target[1]

MAO-B

37.1 nM (IC50)

AChE

31.8 nM (IC50)

In Vitro

Ladostigil (1-10 µM) hemitartrate exerts neuroprotective activities, including a prevention of the fall of the mitochondrial membrane potential (ψ), attenuation of apoptotic cascades and an inhibition of ROS production induced by OS insults[2].
Ladostigil (1-10 µM) hemitartrate has a significant neuroprotective activity, including inhibition of caspase-3 activation, induction of Bcl-2 and reduction of Bad and Bax gene and protein expression in human neuroblastoma SK-N-SH cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ladostigil (17 mg/kg; p.o. daily for 6 weeks) hemitartrate abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats[4].
Ladostigil (50 μmol/kg; single p.o.) hemitartrate restores the loss of episodic memory in the object recognition test in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pathogen-free (SPF) Sprague-Dawley rats[4]
Dosage: 17 mg/kg
Administration: P.o. (added to the drinking water) daily for 6 weeks
Result: Inhibited brain MAO-A and B by more than 60%.
Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST.
Molecular Weight

694.77

Formula

C₁₆H₂₀N₂O₂.₁/₂C₄H₆O₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (71.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4393 mL 7.1966 mL 14.3933 mL
5 mM 0.2879 mL 1.4393 mL 2.8787 mL
10 mM 0.1439 mL 0.7197 mL 1.4393 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (1.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (1.80 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (1.80 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Ladostigil hemitartrate
Cat. No.:
HY-10400
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