1. Neuronal Signaling
  2. Monoamine Oxidase
    AChE
  3. Ladostigil

Ladostigil (Synonyms: TV-3326)

Cat. No.: HY-10399
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Ladostigil (TV-3326) is a dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with an IC50 of 37.1 and 31.8 μM for MAO-B and AChE, reapectively. Ladostigil could increase cholinergic transmission, prevent the formation of ROS or their actions and be used for the research of depression and Alzheimer's disease.

For research use only. We do not sell to patients.

Ladostigil Chemical Structure

Ladostigil Chemical Structure

CAS No. : 209394-27-4

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Description

Ladostigil (TV-3326) is a dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with an IC50 of 37.1 and 31.8 μM for MAO-B and AChE, reapectively. Ladostigil could increase cholinergic transmission, prevent the formation of ROS or their actions and be used for the research of depression and Alzheimer's disease[1][2].

IC50 & Target[1]

MAO-B

37.1 μM (IC50)

AChE

31.8 μM (IC50)

In Vitro

Ladostigil (1-10 µM) exerts neuroprotective activities, including a prevention of the fall of the mitochondrial membrane potential (ψ), attenuation of apoptotic cascades and an inhibition of ROS production induced by OS insults[2].
Ladostigil (1-10 µM) has a significant neuroprotective activity, including inhibition of caspase-3 activation, induction of Bcl-2 and reduction of Bad and Bax gene and protein expression in human neuroblastoma SK-N-SH cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ladostigil (17 mg/kg; p.o. daily for 6 weeks) abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats[4].
Ladostigil (50 μmol/kg; single p.o.) restores the loss of episodic memory in the object recognition test in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pathogen-free (SPF) Sprague-Dawley rats[4]
Dosage: 17 mg/kg
Administration: P.o. (added to the drinking water) daily for 6 weeks
Result: Inhibited brain MAO-A and B by more than 60%.
Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST.
Molecular Weight

272.34

Formula

C₁₆H₂₀N₂O₂

CAS No.

209394-27-4

SMILES

O=C(OC1=CC2=C(CC[[email protected]]2NCC#C)C=C1)N(CC)C

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LadostigilTV-3326TV3326TV 3326Monoamine OxidaseAChEMAOAcetylcholinesterasemonoamineoxidaseacetylcholinesteraseMAO-BdepressionAlzheimerInhibitorinhibitorinhibit

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