Rasagiline mesylate
Based on 8 publication(s) in Google Scholar
Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively. Rasagiline (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- Pureté : 99.82%
- CAS No.: 161735-79-1
- Formule: C13H17NO3S
- Masse moléculaire:267.34
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Rasagiline mesylate
More- J Neuroinflammation. 2025 Apr 29;22(1):125. [Abstract]
- Eur J Med Chem. 2024 Dec 5:279:116842. [Abstract]
- Eur J Med Chem. 2023 Jul 5:255:115417. [Abstract]
- Bioorg Chem. 2023 Sep:138:106654. [Abstract]
- Front Cell Neurosci. 2018 Sep 11:12:309. [Abstract]
- Behav Brain Res. 2024 Feb 29:459:114787. [Abstract]
- J Nat Med. 2026 Sep;80(5):1461-1475.
- Oncotarget. 2018 Jan 30;9(15):12137-12153. [Abstract]
Customer Validation & Images
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Activité biologique
Description
IC50 & Target
[1]|
rMAO-B 4.43 nM (IC50) |
rMAO-A 412 nM (IC50) |
In Vitro
Rasagiline (0.25 nM; 96 hours) significantly increases the proliferation rates of SH-SY5Y and 1242-MG upon Dexamethasone (10 μM) treatment[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:Neuroblastoma SH-SY5Y, and glioblastoma 1242-MG
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Concentration:0.25 nM
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Incubation Time:96 hours
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Result:Caused ~60% increase in the cell proliferation rate for SH-SY5Y cells treated with Dexamethasone.
Caused ~35% increase in cell proliferation rate for 1242-MG cells treated with Dexamethasone.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:(PLP)-α-synuclein transgenic mice over 6 months of age[3]
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Dosage:Low-(0.8 mg/kg b.w.) and high dose (2.5 mg/kg b. w.)
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Administration:Administered subcutaneously every 24 h for a total period of 4 weeks (from day 1 till day 28 of the experiment).
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Result:Low dose treatment did not show protective efficacy in striatum with number of neurons similar to placebo treated MSA mice. High dose was associated with about 15% rescue of DARPP-32 immunoreactive striatal neurons.
Low dose treatment had no effect on nigral neuronal loss, but high dose completely protected nigral neurons with numbers comparable to healthy controls.
Chemical Information
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CAS No. 161735-79-1
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Appearance Solid
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Masse moléculaire 267.34
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Formule C13H17NO3S
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Color White to off-white
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SMILES
CS(=O)(O)=O.C#CCN[C@H]1C2=CC=CC=C2CC1
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Synonyms
(R)-AGN1135 mesylate; TVP1012 mesylate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (8)
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Journal Impact Factor
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Most Recent
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J Neuroinflammation
Repurposing of epalrestat for neuroprotection in parkinson's disease via activation of the KEAP1/Nrf2 pathway. [Abstract]2025 Apr 29;22(1):125. PMID: 40301912 -
Eur J Med Chem
2024 Dec 5:279:116842. PMID: 39260319 -
Eur J Med Chem
Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease. [Abstract]2023 Jul 5:255:115417. PMID: 37137246 -
Bioorg Chem
Novel flavonoid 1,3,4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway. [Abstract]2023 Sep:138:106654. PMID: 37300959 -
Front Cell Neurosci
Differential Regulation of Adhesion and Phagocytosis of Resting and Activated Microglia by Dopamine. [Abstract]2018 Sep 11:12:309. PMID: 30254570 -
Behav Brain Res
Safinamide alleviates hyperalgesia via inhibiting hyperexcitability of DRG neurons in a mouse model of Parkinson's disease. [Abstract]2024 Feb 29:459:114787. PMID: 38042302 -
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Oncotarget
Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. [Abstract]2018 Jan 30;9(15):12137-12153. PMID: 29552298
Rasagiline mesylate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2018 Jan 30;9(15):12137-12153. [Abstract]
Retinal protection of Rasagiline combined with Idebenone against retinal ischemia-reperfusion (RIR) injury. Western blot analysis for the expression level of brain-derived neurotrophic factor (BDNF) in the whole IR-injured retinas.
Solvant et solubilité
In Vitro:
H2O : 25 mg/mL (93.51 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (374.06 mM); Clear solution; Need ultrasonic
Protocole
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EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
The EdU incorporation assay measures DNA synthesis by adding the thymidine analog 5-ethynyl-2′-deoxyuridine to cells or tissues, where it is incorporated into newly synthesized DNA during S phase. Incorporated EdU is detected by copper-catalyzed azide-alkyne cycloaddition, in which a fluorescent azide covalently reacts with the ethynyl group on EdU, allowing S-phase cells to be detected by fluorescence microscopy, flow cytometry, or high-content imaging. EdU detection does not require DNA denaturation or anti-BrdU antibody access, which preserves sample structure and improves compatibility with immunostaining and multiparameter cytometry compared with BrdU-based detection. EdU can be cytotoxic in a cell-type- and exposure-dependent manner, so pulse duration, concentration, and continuous-labeling designs should be validated for each cell type.
Pureté et documentation
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Fiche technique (279 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. M B Youdim, et al. Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br J Pharmacol. 2001 Jan;132(2):500-6. [Content Brief]
[2]. Shawna Tazik, et al. Comparative neuroprotective effects of Rasagiline and aminoindan with selegiline on dexamethasone-induced brain cell apoptosis. Neurotox Res. 2009 Apr;15(3):284-90. [Content Brief]
[3]. Nadia Stefanova, et al. Rasagiline is neuroprotective in a transgenic model of multiple system atrophy. Exp Neurol. 2008 Apr;210(2):421-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.7406 mL | 18.7028 mL | 37.4056 mL | 93.5139 mL |
| 5 mM | 0.7481 mL | 3.7406 mL | 7.4811 mL | 18.7028 mL | |
| 10 mM | 0.3741 mL | 1.8703 mL | 3.7406 mL | 9.3514 mL | |
| 15 mM | 0.2494 mL | 1.2469 mL | 2.4937 mL | 6.2343 mL | |
| 20 mM | 0.1870 mL | 0.9351 mL | 1.8703 mL | 4.6757 mL | |
| 25 mM | 0.1496 mL | 0.7481 mL | 1.4962 mL | 3.7406 mL | |
| 30 mM | 0.1247 mL | 0.6234 mL | 1.2469 mL | 3.1171 mL | |
| 40 mM | 0.0935 mL | 0.4676 mL | 0.9351 mL | 2.3378 mL | |
| 50 mM | 0.0748 mL | 0.3741 mL | 0.7481 mL | 1.8703 mL | |
| 60 mM | 0.0623 mL | 0.3117 mL | 0.6234 mL | 1.5586 mL | |
| 80 mM | 0.0468 mL | 0.2338 mL | 0.4676 mL | 1.1689 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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