1. Neuronal Signaling
    Autophagy
    Apoptosis
  2. Monoamine Oxidase
    Autophagy
    Apoptosis
  3. Rasagiline mesylate

Rasagiline mesylate (Synonyms: (R)-AGN1135 mesylate; TVP1012 mesylate)

Cat. No.: HY-14605 Purity: 99.66%
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Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively.

For research use only. We do not sell to patients.

Rasagiline mesylate Chemical Structure

Rasagiline mesylate Chemical Structure

CAS No. : 161735-79-1

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Rasagiline mesylate:

Top Publications Citing Use of Products

    Rasagiline mesylate purchased from MCE. Usage Cited in: Oncotarget. 2018 Jan 30;9(15):12137-12153.

    Retinal protection of Rasagiline combined with Idebenone against retinal ischemia-reperfusion (RIR) injury. Western blot analysis for the expression level of brain-derived neurotrophic factor (BDNF) in the whole IR-injured retinas.

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    • References

    • Customer Review

    Description

    Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively[1].

    IC50 & Target[1]

    rMAO-B

    4.43 nM (IC50)

    rMAO-A

    412 nM (IC50)

    In Vitro

    Rasagiline (0.25 nM; 96 hours) significantly increases the proliferation rates of SH-SY5Y and 1242-MG upon Dexamethasone (10 µM) treatment[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[2]

    Cell Line: Neuroblastoma SH-SY5Y, and glioblastoma 1242-MG
    Concentration: 0.25 nM
    Incubation Time: 96 hours
    Result: Caused ~60% increase in the cell proliferation rate for SH-SY5Y cells treated with Dexamethasone.
    Caused ~35% increase in cell proliferation rate for 1242-MG cells treated with Dexamethasone.
    In Vivo

    Rasagiline is neuroprotective in a transgenic model of multiple system atrophy. Motor behavioural tests show improvements in motor deficits associated with 2.5 mg/kg Rasagiline therapy[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: (PLP)-α-synuclein transgenic mice over 6 months of age[3]
    Dosage: Low-(0.8 mg/kg b.w.) and high dose (2.5 mg/kg b. w.)
    Administration: Administered subcutaneously every 24 h for a total period of 4 weeks (from day 1 till day 28 of the experiment).
    Result: Low dose treatment did not show protective efficacy in striatum with number of neurons similar to placebo treated MSA mice. High dose was associated with about 15% rescue of DARPP-32 immunoreactive striatal neurons.
    Low dose treatment had no effect on nigral neuronal loss, but high dose completely protected nigral neurons with numbers comparable to healthy controls.
    Clinical Trial
    Molecular Weight

    267.34

    Formula

    C₁₃H₁₇NO₃S

    CAS No.

    161735-79-1

    SMILES

    CS(=O)(O)=O.C#CCN[[email protected]]1C2=CC=CC=C2CC1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 25 mg/mL (93.51 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.7406 mL 18.7028 mL 37.4056 mL
    5 mM 0.7481 mL 3.7406 mL 7.4811 mL
    10 mM 0.3741 mL 1.8703 mL 3.7406 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 99.66%

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    Keywords:

    Rasagiline(R)-AGN1135TVP1012TVP 1012TVP-1012Monoamine OxidaseAutophagyApoptosisMAOInhibitorinhibitorinhibit

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    Product Name:
    Rasagiline mesylate
    Cat. No.:
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