Desmethoxyyangonin (Synonyms: Demethoxyyangonin; 5,6-Dehydrokavain)

Cat. No.: HY-N0918 Purity: 99.47%: FAQs
Data Sheet SDS COA Handling Instructions

Desmethoxyyangonin is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.

For research use only. We do not sell to patients.

Desmethoxyyangonin Chemical Structure

CAS No. : 15345-89-8

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 187	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 187	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 288	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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MAO-A MAO-B

Biological Activity
Purity & Documentation
References
Customer Review

Description

Desmethoxyyangonin is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.

Molecular Weight

228.24

Appearance

Solid

Formula

C₁₄H₁₂O₃

CAS No.

15345-89-8

SMILES

O=C1C=C(OC)C=C(/C=C/C2=CC=CC=C2)O1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 14.29 mg/mL (62.61 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.3814 mL	21.9068 mL	43.8135 mL
5 mM	0.8763 mL	4.3814 mL	8.7627 mL
10 mM	0.4381 mL	2.1907 mL	4.3814 mL

*Please refer to the solubility information to select the appropriate solvent.

Purity & Documentation

Purity: 99.47%

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Data Sheet (270 KB) SDS (393 KB)

COA (246 KB) HNMR (225 KB) RP-HPLC (209 KB) MS (176 KB)

Handling Instructions (2659 KB)

References

[1]. Uebelhack R, et al. Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava). Pharmacopsychiatry. 1998 Sep;31(5):187-92. [Content Brief]

[2]. Baum SS, et al. Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Oct;22(7):1105-20. [Content Brief]

[3]. Ma Y, et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. Drug Metab Dispos. 2004 Nov;32(11):1317-24. [Content Brief]

Desmethoxyyangonin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Desmethoxyyangonin15345-89-8Demethoxyyangonin 5,6-DehydrokavainMonoamine OxidaseMAOInhibitorinhibitorinhibit

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