1. Neuronal Signaling
  2. Monoamine Oxidase
  3. Osthenol

Osthenol (Synonyms: Ostenol)

Cat. No.: HY-N2554 Purity: 98.91%
Handling Instructions

Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B.

For research use only. We do not sell to patients.

Osthenol Chemical Structure

Osthenol Chemical Structure

CAS No. : 484-14-0

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1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
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Description

Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B[1].

IC50 & Target[1]

hMAO-A

0.26 μM (Ki)

hMAO-A

0.74 μM (IC50)

Molecular Weight

230.26

Formula

C14H14O3

CAS No.
SMILES

O=C1C=CC2=CC=C(O)C(C/C=C(C)\C)=C2O1

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (434.29 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3429 mL 21.7146 mL 43.4292 mL
5 mM 0.8686 mL 4.3429 mL 8.6858 mL
10 mM 0.4343 mL 2.1715 mL 4.3429 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (10.86 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.86 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.86 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Osthenol
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HY-N2554
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