484-14-0
Chemical Structure
Osthenol
Synonym(s): Ostenol
- CAS. Nr.: 484-14-0
- Formula:C14H14O3
- Molecular Weight:230.26
IUPAC Name: 7-hydroxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
InChIKey: RAKJVIPCCGXHHS-UHFFFAOYSA-N
SMILES: O=C1C=CC2=CC=C(O)C(C/C=C(C)\C)=C2O1
Biological Activity: Osthenol (Ostenol) is a reversible, selective, competitive inhibitor of hMAO-A (IC50=0.74 μM, Ki=0.26 μM), with antifungal and antibacterial activity. Osthenol inhibits the oxidative deamination of hMAO-A and regulates the metabolism of monoamine neurotransmitters. Osthenol also inhibits the PI3K/AKT signaling pathway to induce apoptosis of colon cancer cells, arrest the cell cycle at the G1 phase, and inhibit cell proliferation. Osthenol is mainly used in the study of neurological diseases and cancer, especially depression-related MAO-A targeted intervention and colon cancer[1][2][3][4].
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Osthenol | 99.15% | Osthenol (Ostenol) is a reversible, selective, competitive inhibitor of hMAO-A (IC50=0.74 μM, Ki=0.26 μM), with antifungal and antibacterial activity. Osthenol inhibits the oxidative deamination of hMAO-A and regulates the metabolism of monoamine neurotransmitters. Osthenol also inhibits the PI3K/AKT signaling pathway to induce apoptosis of colon cancer cells, arrest the cell cycle at the G1 phase, and inhibit cell proliferation. Osthenol is mainly used in the study of neurological diseases and cancer, especially depression-related MAO-A targeted intervention and colon cancer. | ||||||||||||||||||||
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- [1]. Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019 Mar 15;29(6):839-843. [Content Brief]
- [2]. Zhuang B, et al. Osthenol inhibits the viability of HCT116 cells through suppressing PI3K/AKT signaling pathway. Int J Clin Exp Pathol, 2017, 10(6): 6308-6315.
- [3]. Montagner C, et al. Antifungal activity of coumarins. Z Naturforsch C J Biosci. 2008 Jan-Feb;63(1-2):21-8. [Content Brief]
- [4]. de Souza SM, et al. Antibacterial activity of coumarins. Z Naturforsch C J Biosci. 2005 Sep-Oct;60(9-10):693-700. [Content Brief]
Keywords
