2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Galanthamine N-Oxide

Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC50 of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes.

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Galanthamine N-Oxide Chemical Structure

Galanthamine N-Oxide Chemical Structure

CAS No. : 134332-50-6

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Galanthamine N-Oxide Related Antibodies

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Description

Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC50 of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes[1][2].

IC50 & Target

AChE

 

BChE

 

Molecular Weight

303.35

Formula

C17H21NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1C=C[C@@]23CC[N@@+](C)([O-])CC4=CC=C(OC)C(O[C@@]3([H])C1)=C24
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 6.25 mg/mL (20.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2965 mL 16.4826 mL 32.9652 mL
5 mM 0.6593 mL 3.2965 mL 6.5930 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.90%

COA (257 KB) HNMR (198 KB) LCMS (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2965 mL 16.4826 mL 32.9652 mL 82.4131 mL
5 mM 0.6593 mL 3.2965 mL 6.5930 mL 16.4826 mL
10 mM 0.3297 mL 1.6483 mL 3.2965 mL 8.2413 mL
15 mM 0.2198 mL 1.0988 mL 2.1977 mL 5.4942 mL
20 mM 0.1648 mL 0.8241 mL 1.6483 mL 4.1207 mL
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Galanthamine N-Oxide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Galanthamine N-Oxide134332-50-6Cholinesterase (ChE)alkaloidsubstrateaccommodationactivesiteInhibitorinhibitorinhibit

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