Desoxypeganine (Synonyms: Deoxypeganine; Deoxyvasicine)

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Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC₅₀ values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research.

For research use only. We do not sell to patients.

Desoxypeganine Chemical Structure

CAS No. : 495-59-0

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AChE BChE

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MAO-A MAO-B

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

BChE

2 μM (IC₅₀)

AChE

17 μM (IC₅₀)

MAO-A

2 μM (IC₅₀)

In Vivo

Desoxypeganine (10-30 mg/kg, gavage, once daily for 16 days) reduced ethanol intake and ethanol preference dose-dependently^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Alko alcohol (AA) rats (Thirty eight adult)^[1]
Dosage:	10, 20, 30 mg/kg
Administration:	Gavage, once daily in a volume of 10 ml/kg at 6:00 pm, for 16 days
Result:	Abolished ethanol preference.

Molecular Weight

172.23

Formula

C₁₁H₁₂N₂

CAS No.

495-59-0

SMILES

C12=NC3=C(C=CC=C3)CN1CCC2

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Doetkotte R, et al. Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol. 2005 Oct 17;522(1-3):72-7. [Content Brief]

[2]. Zheng XY, et al. Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay. Arch Pharm Res. 2009 Sep;32(9):1245-51. [Content Brief]

Desoxypeganine Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desoxypeganine495-59-0Deoxypeganine DeoxyvasicineCholinesterase (ChE)Monoamine OxidaseMAOPeganum harmala L.butyrylcholinesteraseacetylcholinesteraseAlko alcoholalcohol abuseInhibitorinhibitorinhibit

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