Desoxypeganine
Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC50 values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research.
For research use only. We do not sell to patients.
- CAS No.: 495-59-0
- Formula: C11H12N2
- Molecular Weight:172.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BChE 2 μM (IC50) |
AChE 17 μM (IC50) |
MAO-A 2 μM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Alko alcohol (AA) rats (Thirty eight adult)[1]
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Dosage:10, 20, 30 mg/kg
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Administration:Gavage, once daily in a volume of 10 ml/kg at 6:00 pm, for 16 days
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Result:Abolished ethanol preference.
Chemical Information
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CAS No. 495-59-0
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Molecular Weight 172.23
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Formula C11H12N2
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SMILES
C12=NC3=C(C=CC=C3)CN1CCC2
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Synonyms
Deoxypeganine; Deoxyvasicine
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Doetkotte R, et al. Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol. 2005 Oct 17;522(1-3):72-7. [Content Brief]
[2]. Zheng XY, et al. Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay. Arch Pharm Res. 2009 Sep;32(9):1245-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Desoxypeganine Related Classifications
HY-108048 Related Classifications
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