AChE-IN-12
AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC50s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC50 = 8.8 μM). AChE-IN-12 has remarkable inhibition of self- and Cu2+-induced Aβ1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease.
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- CAS. Nr.: 2764664-52-8
- Formel: C33H41NO7
- Molecular Weight:563.68
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
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AChE |
In Vitro
AChE-IN-12 (compound 17f）(10-100 μM) exhibits no obvious cytotoxicity until the concentration increased up to 50 μM[1].
AChE-IN-12 (10 and 50 μM) adds up the cell viability of H2O2-induced PC12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12 cells[1]
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Concentration:10, 50 and 100 μM
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Incubation Time:
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Result:Did not show obvious cytotoxicity until the concentration increased up to 50 µM.
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Cell Line:PC12 cells (exposed to 100 µM H2O2 for 1 hour to establish the oxidative damage model)[1]
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Concentration:10 and 50 μM
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Incubation Time:
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Result:Added up the cell viability to 65.7% (p < 0.05) and 73.4% (p < 0.05) at 10 and 50 μM, respectively.
Chemical Information
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CAS. Nr. 2764664-52-8
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Molecular Weight 563.68
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Formel C33H41NO7
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SMILES
O=C(C1=C(O)C=C(OC)C(O)=C1OC)/C=C/C2=CC=C(OCCCCCCN(CC)CC3=CC=CC=C3OC)C=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AChE-IN-12 Related Classifications
HY-144790 Related Classifications
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