AChE-IN-12
AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC50s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC50 = 8.8 μM). AChE-IN-12 has remarkable inhibition of self- and Cu2+-induced Aβ1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease.
For research use only. We do not sell to patients.
- CAS No.: 2764664-52-8
- Formula: C33H41NO7
- Molecular Weight:563.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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AChE |
In Vitro
AChE-IN-12 (compound 17f）(10-100 μM) exhibits no obvious cytotoxicity until the concentration increased up to 50 μM[1].
AChE-IN-12 (10 and 50 μM) adds up the cell viability of H2O2-induced PC12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:PC12 cells[1]
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Concentration:10, 50 and 100 μM
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Incubation Time:
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Result:Did not show obvious cytotoxicity until the concentration increased up to 50 µM.
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Cell Line:PC12 cells (exposed to 100 µM H2O2 for 1 hour to establish the oxidative damage model)[1]
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Concentration:10 and 50 μM
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Incubation Time:
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Result:Added up the cell viability to 65.7% (p < 0.05) and 73.4% (p < 0.05) at 10 and 50 μM, respectively.
Chemical Information
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CAS No. 2764664-52-8
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Molecular Weight 563.68
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Formula C33H41NO7
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SMILES
O=C(C1=C(O)C=C(OC)C(O)=C1OC)/C=C/C2=CC=C(OCCCCCCN(CC)CC3=CC=CC=C3OC)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-12 Related Classifications
HY-144790 Related Classifications
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