(-)-Carvone

Cat. No.: HY-W017423 Purity: 99.41%: FAQs
Data Sheet SDS COA Handling Instructions

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(-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae.

For research use only. We do not sell to patients.

(-)-Carvone Chemical Structure

CAS No. : 6485-40-1

Size	Price	Stock	Quantity
25 g	USD 30	In-stock	Estimated Time of Arrival: December 31
50 g	USD 40	In-stock	Estimated Time of Arrival: December 31
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This product is a controlled substance and not for sale in your territory.

Other Forms of (-)-Carvone:

Carvone In-stock
(S)-(+)-Carvone In-stock

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AChE BChE

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

eel AChE

2.19 mM (Ki)

In Vitro

(-)-Carvone (3.04 mM; 30 min) inactivates eel AChE with K_i value of 2.19 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(-)-Carvone (5% in absolute ethanol v/v, 20 μL; application to the thoraces ventral surfaces) inhibits AChE such as horse serum cholinesterase, house fly head cholinesterases, and head and thorax cholinesterases from the Madagascar roach in vitro^[1].
(-)-Carvone (0.05%-0.1% w/v; p.o.; 7 d) inhibits E. insulana larvae growth, decreases weight of larvae^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female roaches (Gromphadorhina portentosa) (6.4 g-6.8 g)^[1]
Dosage:	5% in absolute ethanol v/v, 20 μL
Administration:	Application to the ventral surfaces of their thoraces; decapitated and crude at various time intervals (0, 2, 4, 5, 20, 24, and 26 hr)
Result:	Inhibited the activity of AChE in the extracts of both the head and thorax.

Molecular Weight

150.22

Formula

C₁₀H₁₄O

CAS No.

6485-40-1

Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C1C(C)=CC[C@@H](C(C)=C)C1

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (665.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.6569 mL	33.2845 mL	66.5690 mL
5 mM	1.3314 mL	6.6569 mL	13.3138 mL
10 mM	0.6657 mL	3.3285 mL	6.6569 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.41%

Select Batch:

Data Sheet (273 KB) SDS (0 KB)

COA (248 KB) HNMR (121 KB) GC (197 KB) OR (92 KB)

Handling Instructions (2659 KB)

References

[1]. Grundy D L, et al. Inhibition of acetylcholinesterases by pulegone-1, 2-epoxide[J]. Pesticide biochemistry and physiology, 1985, 23(3): 383-388.

[2]. Meisner J, et al. The response of Earias insulana Boisd. larvae to phagodeterrent (–)‐carvone incorporated in an artificial diet 1[J]. Zeitschrift für Angewandte Entomologie, 1980, 90(1‐5): 80-82.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.6569 mL	33.2845 mL	66.5690 mL	166.4226 mL
	5 mM	1.3314 mL	6.6569 mL	13.3138 mL	33.2845 mL
	10 mM	0.6657 mL	3.3285 mL	6.6569 mL	16.6423 mL
	15 mM	0.4438 mL	2.2190 mL	4.4379 mL	11.0948 mL
	20 mM	0.3328 mL	1.6642 mL	3.3285 mL	8.3211 mL
	25 mM	0.2663 mL	1.3314 mL	2.6628 mL	6.6569 mL
	30 mM	0.2219 mL	1.1095 mL	2.2190 mL	5.5474 mL
	40 mM	0.1664 mL	0.8321 mL	1.6642 mL	4.1606 mL
	50 mM	0.1331 mL	0.6657 mL	1.3314 mL	3.3285 mL
	60 mM	0.1109 mL	0.5547 mL	1.1095 mL	2.7737 mL
	80 mM	0.0832 mL	0.4161 mL	0.8321 mL	2.0803 mL
	100 mM	0.0666 mL	0.3328 mL	0.6657 mL	1.6642 mL

(-)-Carvone Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Carvone6485-40-1Cholinesterase (ChE)insect neurotoxinirreversiblebird repellentlarval growthpupatation ratemortality of larvaeInhibitorinhibitorinhibit

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