2. Neuronal Signaling Anti-infection Metabolic Enzyme/Protease
  3. Parasite Cholinesterase (ChE) Endogenous Metabolite
  4. Coumaran

Coumaran  (Synonyms: 2,3-Dihydrobenzofuran)

Cat. No.: HY-75247 Purity: 99.54%
COA Handling Instructions

Molarity Calculator

Coumaran (2,3-Dihydrobenzofuran) is an AChE inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide..

For research use only. We do not sell to patients.

Coumaran Chemical Structure

Coumaran Chemical Structure

CAS No. : 496-16-2

Size Price Stock Quantity
Liquid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 In-stock
Solution
10 mM * 1 mL in DMSO USD 33 In-stock
Liquid
5 g USD 30 In-stock
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50 g   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Coumaran Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Coumaran

View All Parasite Isoform Specific Products:

View All Isoforms
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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View All Isoforms
AChE BChE

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Coumaran (2,3-Dihydrobenzofuran) is an AChE inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide.[2].

IC50 & Target

AChE

 

In Vitro

Coumaran is active against promastigote (IC50=1.042 μM) and amastigote (IC50=1.43 μM) forms, demonstrating potent antileishmanial activity [2].
Coumaran (0.5-13 μM; 48 h) Not significantly cytotoxic to macrophages or erythrocytes [2].
Coumaran (0.5-13 μM; 24 h) increases phagocyte and lysosomal activity and nitrite (NO2- ) level [2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Coumaran Related Antibodies

Cell Viability Assay[2]

Cell Line: Promastigotes
Concentration: 0.4, 0.8 and 1.6 µM
Incubation Time: 48 h
Result: Demonstrated a concentration-dependent reduction in infection of macrophages by 7.0, 22.0 and 33.34% for 0.4, 0.8 and 1.6 µM, respectively.
Molecular Weight

120.15

Formula

C8H8O
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

C12=CC=CC=C1CCO2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 150 mg/mL (1248.44 mM; Need ultrasonic)

DMSO : 150 mg/mL (1248.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.3229 mL 41.6146 mL 83.2293 mL
5 mM 1.6646 mL 8.3229 mL 16.6459 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 3.75 mg/mL (31.21 mM); Clear solution

    This protocol yields a clear solution of ≥ 3.75 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 3.75 mg/mL (31.21 mM); Clear solution

    This protocol yields a clear solution of ≥ 3.75 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (832.29 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.54%

COA (254 KB) RP-HPLC (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 8.3229 mL 41.6146 mL 83.2293 mL 208.0732 mL
5 mM 1.6646 mL 8.3229 mL 16.6459 mL 41.6146 mL
10 mM 0.8323 mL 4.1615 mL 8.3229 mL 20.8073 mL
15 mM 0.5549 mL 2.7743 mL 5.5486 mL 13.8715 mL
20 mM 0.4161 mL 2.0807 mL 4.1615 mL 10.4037 mL
25 mM 0.3329 mL 1.6646 mL 3.3292 mL 8.3229 mL
30 mM 0.2774 mL 1.3872 mL 2.7743 mL 6.9358 mL
40 mM 0.2081 mL 1.0404 mL 2.0807 mL 5.2018 mL
50 mM 0.1665 mL 0.8323 mL 1.6646 mL 4.1615 mL
60 mM 0.1387 mL 0.6936 mL 1.3872 mL 3.4679 mL
80 mM 0.1040 mL 0.5202 mL 1.0404 mL 2.6009 mL
100 mM 0.0832 mL 0.4161 mL 0.8323 mL 2.0807 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Coumaran Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Coumaran496-16-22,3-DihydrobenzofuranParasiteCholinesterase (ChE)Endogenous MetaboliteacetylcholinesteraseAChEbiopesticideInhibitorinhibitorinhibit

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