2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. SB-1436

SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC50s of 0.176, 0.37 and 0.08 μM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with Kis of 0.046 and 0.115 μM, respectively. SB-1436 significantly stops the self-aggregation of Aβ, and can be used for neurological disease research.

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SB-1436 Chemical Structure

SB-1436 Chemical Structure

CAS No. : 2925298-08-2

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SB-1436 Related Antibodies

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Description

SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC50s of 0.176, 0.37 and 0.08 μM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with Kis of 0.046 and 0.115 μM, respectively. SB-1436 significantly stops the self-aggregation of Aβ, and can be used for neurological disease research[1].

IC50 & Target[1]

EeAChE

0.176 μM (IC50)

eqBCHE

0.37 μM (IC50)

EeAChE

0.046 μM (Ki)

eqBCHE

0.115 μM (Ki)

In Vitro

SB-1436 (Compound 7av) (1 μM, 20 min) inhibits AChE, BChE and rHuAChE with IC50s of 0.176, 0.37 and 0.08 μM, respectively[1].
SB-1436 (0.78-100 μM, 48 hours) reduces the cell viability in J774A.1 and primary astrocytes cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SB-1436 Related Antibodies

Cell Viability Assay[1]

Cell Line: J774A.1 cells and primary astrocytes
Concentration: 0.78-100 μM
Incubation Time: 48 hours
Result: Reduced the cell viability in J774A.1 and primary astrocytes cell lines, and its GI50 in both cell types is ∼6.25 μM.
Molecular Weight

405.89

Formula

C25H21ClFNO
CAS No.
SMILES

COC1=CC2=C(C=C(/C=C/C3=CC=[N+](CC4=CC=C(F)C=C4)C=C3)C=C2)C=C1.[Cl-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SB-1436 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-14362925298-08-2SB1436SB 1436Cholinesterase (ChE)Cholinesterase inhibitorJ774A.1primary astrocytesAlzheimer’s diseaseADInhibitorinhibitorinhibit

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