2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Pralidoxime iodide

Pralidoxime iodide 

Cat. No.: HY-B1738A Purity: ≥98.0%
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Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning.

For research use only. We do not sell to patients.

Pralidoxime iodide Chemical Structure

Pralidoxime iodide Chemical Structure

CAS No. : 94-63-3

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Based on 1 publication(s) in Google Scholar

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Description

Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2].

In Vivo

Pralidoxime iodide (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male F1B6D2 mice (toxic but non-lethal model of diethylparaoxon in awake, unrestrained mice)[3]
Dosage: 10, 50, 100 and 150 mg/kg
Administration: Intramuscularly, once
Result: Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.
Clinical Trial
Molecular Weight

264.06

Appearance

Solid

Formula

C7H9IN2O
CAS No.
SMILES

C[N+]1=CC=CC=C1/C=N/O.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (946.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7870 mL 18.9351 mL 37.8702 mL
5 mM 0.7574 mL 3.7870 mL 7.5740 mL
10 mM 0.3787 mL 1.8935 mL 3.7870 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Pralidoxime94-63-3Cholinesterase (ChE)respiratorytoxicitynerveantidoteorganophosphatepoisoningInhibitorinhibitorinhibit

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