1. Neuronal Signaling
  2. AChE
  3. Pralidoxime iodide

Pralidoxime iodide 

Cat. No.: HY-B1738A Purity: >98.0%
Handling Instructions

Pralidoxime iodide is a reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent, which inhibits AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning.

For research use only. We do not sell to patients.

Pralidoxime iodide Chemical Structure

Pralidoxime iodide Chemical Structure

CAS No. : 94-63-3

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10 mM * 1  mL in DMSO USD 11 In-stock
Estimated Time of Arrival: December 31
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250 mg USD 40 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Pralidoxime iodide is a reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent, which inhibits AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2].

In Vivo

Pralidoxime iodide (10-150 mg/kg; i.m.) reverses paraoxon-induced respiratory toxicity in mice[3].

Animal Model: Male F1B6D2 mice (toxic but non-lethal model of diethylparaoxon in awake, unrestrained mice)[3]
Dosage: 10, 50, 100 and 150 mg/kg
Administration: Intramuscularly
Result: Reversal of diethylparaoxon-induced respiratory toxicity at 150 mg/kg.
Molecular Weight

264.06

Formula

C₇H₉IN₂O

CAS No.

94-63-3

SMILES

C[N+]1=CC=CC=C1/C=N/O.[I-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (946.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7870 mL 18.9351 mL 37.8702 mL
5 mM 0.7574 mL 3.7870 mL 7.5740 mL
10 mM 0.3787 mL 1.8935 mL 3.7870 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

PralidoximeAChEAcetylcholinesteraserespiratorytoxicitynerveantidoteorganophosphatepoisoningInhibitorinhibitorinhibit

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Pralidoxime iodide
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HY-B1738A
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