Pralidoxime iodide

Name: Pralidoxime iodide
Brand: MedChemExpress
SKU: HY-B1738A
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1738A Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning.

For research use only. We do not sell to patients.

Pralidoxime iodide Chemical Structure

CAS No. : 94-63-3

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 28	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 28	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 37	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 49	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Pralidoxime iodide:

Pralidoxime Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Cholinesterase (ChE) Isoform Specific Products:

View All Isoforms

AChE BChE

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

AChE

In Vivo

Pralidoxime iodide (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male F1B6D2 mice (toxic but non-lethal model of diethylparaoxon in awake, unrestrained mice)^[3]
Dosage:	10, 50, 100 and 150 mg/kg
Administration:	Intramuscularly, once
Result:	Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.

Clinical Trial

Molecular Weight

264.06

Formula

C₇H₉IN₂O

CAS No.

94-63-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

C[N+]1=CC=CC=C1/C=N/O.[I-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (946.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7870 mL	18.9351 mL	37.8702 mL
5 mM	0.7574 mL	3.7870 mL	7.5740 mL
10 mM	0.3787 mL	1.8935 mL	3.7870 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (247 KB) HNMR (227 KB)

Handling Instructions (2659 KB)

References

[1]. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141. [Content Brief]

[2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111. [Content Brief]

[3]. Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46(2):131‐138. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7870 mL	18.9351 mL	37.8702 mL	94.6755 mL
	5 mM	0.7574 mL	3.7870 mL	7.5740 mL	18.9351 mL
	10 mM	0.3787 mL	1.8935 mL	3.7870 mL	9.4675 mL
	15 mM	0.2525 mL	1.2623 mL	2.5247 mL	6.3117 mL
	20 mM	0.1894 mL	0.9468 mL	1.8935 mL	4.7338 mL
	25 mM	0.1515 mL	0.7574 mL	1.5148 mL	3.7870 mL
	30 mM	0.1262 mL	0.6312 mL	1.2623 mL	3.1558 mL
	40 mM	0.0947 mL	0.4734 mL	0.9468 mL	2.3669 mL
	50 mM	0.0757 mL	0.3787 mL	0.7574 mL	1.8935 mL
	60 mM	0.0631 mL	0.3156 mL	0.6312 mL	1.5779 mL
	80 mM	0.0473 mL	0.2367 mL	0.4734 mL	1.1834 mL
	100 mM	0.0379 mL	0.1894 mL	0.3787 mL	0.9468 mL