2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. TZ4M

TZ4M is a 2,4-thiazolidinedione (TZD)-based anti-ADV agent with neuroprotective effects. TZ4M exhibits AChE inhibition in human plasma. TZ4M improves memory and cognitive impairment in adult rats in a scopolamine (HY-N0296)-induced Alzheimer-type model.

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TZ4M Chemical Structure

TZ4M Chemical Structure

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TZ4M Related Antibodies

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Description

TZ4M is a 2,4-thiazolidinedione (TZD)-based anti-ADV agent with neuroprotective effects. TZ4M exhibits AChE inhibition in human plasma. TZ4M improves memory and cognitive impairment in adult rats in a scopolamine (HY-N0296)-induced Alzheimer-type model[1].

IC50 & Target

AChE[1]
In Vivo

In rat model, TZ4M (2 and 3 mg/kg; ip; once daily for 8 days) inhibits Scopolamine (3 mg/kg; ip) induced neuronal damage in the hippocampus and apoptosis of hippocampus neurons and cortexin, and expands the number of mAChR M1 in neurons of the DG region and CA1 of the hippocampus and cortex[1].
TZ4M is encountered to be BBB positive via CBligand-BBB forecast, which is needed for AChE inhibition[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

353.39

Formula

C19H15NO4S
SMILES

O=C(N(CC(C1=CC=CC=C1)=O)C/2=O)SC2=C\C3=CC=C(OC)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TZ4M Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TZ4MCholinesterase (ChE)Alzheimer's diseaseThiazolidine-2,4-dioneacetylcholinesteraseanti-Alzheimer’s agentscholinergic pathwaydementiaInhibitorinhibitorinhibit

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