1. Neuronal Signaling
    NF-κB
  2. AChE
    Keap1-Nrf2
  3. Corynoline

Corynoline 

Cat. No.: HY-N0826 Purity: 98.06%
Handling Instructions

Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM. Corynoline exhibits anti-inflammatory activity by activating Nrf2.

For research use only. We do not sell to patients.

Corynoline Chemical Structure

Corynoline Chemical Structure

CAS No. : 18797-79-0

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5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
20 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].

Molecular Weight

367.40

Formula

C₂₁H₂₁NO₅

CAS No.

18797-79-0

SMILES

C[[email protected]@]1(C(C=CC2=C3OCO2)=C3CN4C)[[email protected]@]4([H])C(C=C(OCO5)C5=C6)=C6C[[email protected]@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (113.42 mM; Need ultrasonic)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7218 mL 13.6091 mL 27.2183 mL
5 mM 0.5444 mL 2.7218 mL 5.4437 mL
10 mM 0.2722 mL 1.3609 mL 2.7218 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

CorynolineAChEKeap1-Nrf2AcetylcholinesteraseInhibitorinhibitorinhibit

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Corynoline
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