1. Neuronal Signaling
    Metabolic Enzyme/Protease
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  2. AChE
    Beta-secretase
    Reactive Oxygen Species
  3. Epiberberine chloride

Epiberberine chloride 

Cat. No.: HY-N0226A Purity: 99.60%
Handling Instructions

Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways. Epiberberine has the potential effect in the research of diabetic disease.

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Epiberberine chloride Chemical Structure

Epiberberine chloride Chemical Structure

CAS No. : 889665-86-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 251 In-stock
Estimated Time of Arrival: December 31
5 mg USD 228 In-stock
Estimated Time of Arrival: December 31
10 mg USD 348 In-stock
Estimated Time of Arrival: December 31
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Description

Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways[2]. Epiberberine has the potential effect in the research of diabetic disease[3].

In Vitro

Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes, with an IC50 of 52.8 μM[2].
Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation[2].
Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner[3].

In Vivo

Epiberberine (225 mg/kg, p.o. daily for 40 days) reduces body weight, food consumption, water intake, and urinary output of KK-Ay mice[3].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 7.4 mg/mL (19.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6895 mL 13.4477 mL 26.8955 mL
5 mM 0.5379 mL 2.6895 mL 5.3791 mL
10 mM 0.2690 mL 1.3448 mL 2.6895 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

371.81

Formula

C₂₀H₁₈ClNO₄

CAS No.

889665-86-5

SMILES

COC1=C(OC)C=C2C(CC[N+]3=C2C=C(C=C4)C(C5=C4OCO5)=C3)=C1.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Epiberberine chloride
Cat. No.:
HY-N0226A
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Epiberberine chloride

Cat. No.: HY-N0226A