1. Neuronal Signaling
  2. AChE
    Beta-secretase
  3. Epiberberine

Epiberberine 

Cat. No.: HY-N0226 Purity: 98.46%
Handling Instructions

Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and can be used for the research of Alzheimer disease. Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways. Epiberberinecan be used for the research of diabetic disease.

For research use only. We do not sell to patients.

Epiberberine Chemical Structure

Epiberberine Chemical Structure

CAS No. : 6873-09-2

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5 mg USD 90 In-stock
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10 mg USD 120 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and can be used for the research of Alzheimer disease[1]. Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways[2]. Epiberberinecan be used for the research of diabetic disease[3].

IC50 & Target

IC50: 1.07 μM (AChE), 6.03 μM (BChE), 8.55 μM (BACE1)[2]

In Vitro

Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes, with an IC50 of 52.8 μM[2].
Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation[2].
Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Epiberberine (225 mg/kg, p.o. daily for 40 days) reduces body weight, food consumption, water intake, and urinary output of KK-Ay mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

336.36

Formula

C₂₀H₁₈NO₄+

CAS No.

6873-09-2

SMILES

COC1=C(OC)C=C2C(CC[N+]3=C2C=C(C=C4)C(C5=C4OCO5)=C3)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

EpiberberineAChEBeta-secretaseAcetylcholinesteraseBACEβ-SecretaseInhibitorinhibitorinhibit

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