1. Signaling Pathways
  2. Neuronal Signaling
  3. Beta-secretase
  4. BACE1 Isoform

BACE1

 

BACE1 Related Products (10):

Cat. No. Product Name Effect Purity
  • HY-109052
    Atabecestat
    Inhibitor 98.76%
    Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction.
  • HY-N0226
    Epiberberine
    Inhibitor 98.46%
    Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively.
  • HY-N0226A
    Epiberberine chloride
    Inhibitor 99.03%
    Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively.
  • HY-111383
    LX2343
    Inhibitor 99.80%
    LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM.
  • HY-N2284
    Sophoflavescenol
    Inhibitor 98.15%
    Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC50 of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC50s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.
  • HY-136742
    BACE2-IN-1
    Inhibitor
    BACE2-IN-1 (compound 3l) is a highly selective BACE2 inhibitor with a Ki value of 1.6 nM.
  • HY-12938
    AMG-8718
    Inhibitor
    AMG-8718 is a potent, selective and orally active BACE1 inhibitor with IC50 values of 0.0007, 0.005 µM for BACE1 and BACE2, respectively.
  • HY-151260
    AChE/BACE1/GSK3β-IN-1
    Inhibitor
    AChE/BACE1/GSK3β-IN-1 is an orally active triple inhibitor of AChE/BACE1/GSK3β.
  • HY-112444
    BACE1-IN-2
    Inhibitor
    BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC50 of 22 nM.
  • HY-151348
    BACE1-IN-11
    Inhibitor
    BACE1-IN-11 is a BACE1 inhibitor.