2. Apoptosis Metabolic Enzyme/Protease Neuronal Signaling
  3. Apoptosis Endogenous Metabolite Beta-secretase
  4. Se-Methylselenocysteine

Se-Methylselenocysteine  (Synonyms: Methylselenocysteine; Se-Methylseleno-L-cysteine)

Cat. No.: HY-114245 Purity: ≥98.0%
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Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis.

For research use only. We do not sell to patients.

Se-Methylselenocysteine Chemical Structure

Se-Methylselenocysteine Chemical Structure

CAS No. : 26046-90-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 44 In-stock
Solution
10 mM * 1 mL in Water USD 44 In-stock
Solid
5 mg USD 40 In-stock
10 mg USD 65 In-stock
25 mg USD 140 In-stock
50 mg USD 220 In-stock
100 mg USD 330 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Se-Methylselenocysteine:

Se-Methylselenocysteine Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis[1][2].

IC50 & Target

BACE1

 

In Vitro

Se-Methylselenocysteine (100-400 μM; 3 days) induces apoptosis in SKOV-33 cells[1].
? Se-Methylselenocysteine (100-400 μM; 3 days) induces caspase-3 mediated apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Se-Methylselenocysteine Related Antibodies

Apoptosis Analysis[1]

Cell Line: SKOV-3 cells
Concentration: 100, 200, 400 μM
Incubation Time: 3 days
Result: Resulted in a markedly increased accumulation of Sub-G1 phase, which occurred in both SeMSC concentration and culture time-dependent.

Western Blot Analysis[1]

Cell Line: SKOV-3 cells
Concentration: 100, 200, 400 μM
Incubation Time: 3 days
Result: Resulted in a decrease in the expression of the 32 kDa form of procaspase-3.
In Vivo

Se-Methylselenocysteine (0.2?mg/mouse; p.o.; daily for 14 days) potentiates the antitumour activity of CDDP and Cyclophosphamide in nude mice bearing human FaDu and A253 head and neck xenografts[2].
? Alzheimer's disease (AD) mice are treats with Se-Methylselenocysteine (0.75 mg/kg BW per day) in their drinking water for 10 months. Se-Methylselenocysteine reduces oxidative stress and neuro-inflammation; Se-Methylselenocysteine modulates the distribution and levels of several metal ions; Se-Methylselenocysteine decreases amyloid-β peptide (Aβ) generation by inhibiting the expression of its precursor protein APP and β-secretase (BACE1), and attenuates tau hyperphosphorylation and neurofibrillary tangles (NFT) formation via promoting protein phosphatase 2A (PP2A) activity, thereby preserving synaptic proteins and neuron activities and finally improving spatial learning and memory deficits in AD model mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice (bearing human A253 and FaDu squamous cell carcinoma xenografts)[2]
Dosage: 0.2 mg/mouse
Administration: p.o.; daily for 14 days (7 days before and 7 days after Cyclophosphamide or CDDP in a total of 14 days)
Result:
Clinical Trial
Molecular Weight

182.08

Formula

C4H9NO2Se
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](N)C[Se]C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (457.66 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4921 mL 27.4605 mL 54.9209 mL
5 mM 1.0984 mL 5.4921 mL 10.9842 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (274.60 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (246 KB) HNMR (152 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.4921 mL 27.4605 mL 54.9209 mL 137.3023 mL
5 mM 1.0984 mL 5.4921 mL 10.9842 mL 27.4605 mL
10 mM 0.5492 mL 2.7460 mL 5.4921 mL 13.7302 mL
15 mM 0.3661 mL 1.8307 mL 3.6614 mL 9.1535 mL
20 mM 0.2746 mL 1.3730 mL 2.7460 mL 6.8651 mL
25 mM 0.2197 mL 1.0984 mL 2.1968 mL 5.4921 mL
30 mM 0.1831 mL 0.9153 mL 1.8307 mL 4.5767 mL
40 mM 0.1373 mL 0.6865 mL 1.3730 mL 3.4326 mL
50 mM 0.1098 mL 0.5492 mL 1.0984 mL 2.7460 mL
60 mM 0.0915 mL 0.4577 mL 0.9153 mL 2.2884 mL
80 mM 0.0687 mL 0.3433 mL 0.6865 mL 1.7163 mL
100 mM 0.0549 mL 0.2746 mL 0.5492 mL 1.3730 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Se-Methylselenocysteine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Se-Methylselenocysteine26046-90-2Methylselenocysteine Se-Methylseleno-L-cysteineApoptosisEndogenous MetaboliteBeta-secretaseBACEβ-SecretasecancerchemopreventiveorallyapoptosisSKOV-33cellscaspase-3FaDuA253headneckInhibitorinhibitorinhibit

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