1. Apoptosis Metabolic Enzyme/Protease Neuronal Signaling
  2. Apoptosis Endogenous Metabolite Beta-secretase
  3. Se-Methylselenocysteine

Se-Methylselenocysteine  (Synonyms: Methylselenocysteine; Se-Methylseleno-L-cysteine)

Cat. No.: HY-114245 Purity: ≥98.0%
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Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis.

For research use only. We do not sell to patients.

Se-Methylselenocysteine Chemical Structure

Se-Methylselenocysteine Chemical Structure

CAS No. : 26046-90-2

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Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 44 In-stock
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10 mM * 1 mL in Water USD 44 In-stock
Solid
5 mg USD 40 In-stock
10 mg USD 65 In-stock
25 mg USD 140 In-stock
50 mg USD 220 In-stock
100 mg USD 330 In-stock
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Based on 2 publication(s) in Google Scholar

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Description

Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis[1][2].

IC50 & Target

BACE1

 

In Vitro

Se-Methylselenocysteine (100-400 μM; 3 days) induces apoptosis in SKOV-33 cells[1].
? Se-Methylselenocysteine (100-400 μM; 3 days) induces caspase-3 mediated apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: SKOV-3 cells
Concentration: 100, 200, 400 μM
Incubation Time: 3 days
Result: Resulted in a markedly increased accumulation of Sub-G1 phase, which occurred in both SeMSC concentration and culture time-dependent.

Western Blot Analysis[1]

Cell Line: SKOV-3 cells
Concentration: 100, 200, 400 μM
Incubation Time: 3 days
Result: Resulted in a decrease in the expression of the 32 kDa form of procaspase-3.
In Vivo

Se-Methylselenocysteine (0.2?mg/mouse; p.o.; daily for 14 days) potentiates the antitumour activity of CDDP and Cyclophosphamide in nude mice bearing human FaDu and A253 head and neck xenografts[2].
? Alzheimer's disease (AD) mice are treats with Se-Methylselenocysteine (0.75 mg/kg BW per day) in their drinking water for 10 months. Se-Methylselenocysteine reduces oxidative stress and neuro-inflammation; Se-Methylselenocysteine modulates the distribution and levels of several metal ions; Se-Methylselenocysteine decreases amyloid-β peptide (Aβ) generation by inhibiting the expression of its precursor protein APP and β-secretase (BACE1), and attenuates tau hyperphosphorylation and neurofibrillary tangles (NFT) formation via promoting protein phosphatase 2A (PP2A) activity, thereby preserving synaptic proteins and neuron activities and finally improving spatial learning and memory deficits in AD model mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice (bearing human A253 and FaDu squamous cell carcinoma xenografts)[2]
Dosage: 0.2 mg/mouse
Administration: p.o.; daily for 14 days (7 days before and 7 days after Cyclophosphamide or CDDP in a total of 14 days)
Result:
Clinical Trial
Molecular Weight

182.08

Formula

C4H9NO2Se

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](N)C[Se]C)=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (457.66 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4921 mL 27.4605 mL 54.9209 mL
5 mM 1.0984 mL 5.4921 mL 10.9842 mL
10 mM 0.5492 mL 2.7460 mL 5.4921 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (274.60 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Se-Methylselenocysteine
Cat. No.:
HY-114245
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