Cat. No.: HY-114245

Se-Methylselenocysteine

(Synonyms: Methylselenocysteine; Se-Methylseleno-L-cysteine)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis.

For research use only. We do not sell to patients.

Purity: 99.95%
CAS No.: 26046-90-2
Formula: C₄H₉NO₂Se
Molecular Weight:182.08

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Se-Methylselenocysteine Chemical Structure

CAS No.: 26046-90-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis^[1]^[2].

IC₅₀ & Target

BACE1

All Endogenous Metabolite Isoforms :

All Beta-secretase Isoforms :

BACE1
BACE2

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	54 μM Compound: 2	Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
Hs68	IC₅₀	50 μM Compound: 2	Anticancer activity against human Hs68 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human Hs68 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
MCF7	IC₅₀	193 μM Compound: 2	Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
SW-620	IC₅₀	632.8 μM Compound: 2	Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 34217061]
V79	IC₅₀	472 μM Compound: Se-methyl-L-selenocystine	Cytotoxicity activity against V79 cells Cytotoxicity activity against V79 cells	[PMID: 12852761]

In Vitro

Se-Methylselenocysteine (100-400 μM; 3 days) induces apoptosis in SKOV-33 cells^[1].
? Se-Methylselenocysteine (100-400 μM; 3 days) induces caspase-3 mediated apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

SKOV-3 cells
Concentration:

100, 200, 400 μM
Incubation Time:

3 days
Result:

Resulted in a markedly increased accumulation of Sub-G1 phase, which occurred in both SeMSC concentration and culture time-dependent.

Western Blot Analysis^[1]

Cell Line:

SKOV-3 cells
Concentration:

100, 200, 400 μM
Incubation Time:

3 days
Result:

Resulted in a decrease in the expression of the 32 kDa form of procaspase-3.

In Vivo

Se-Methylselenocysteine (0.2?mg/mouse; p.o.; daily for 14 days) potentiates the antitumour activity of CDDP and Cyclophosphamide in nude mice bearing human FaDu and A253 head and neck xenografts^[2].
? Alzheimer's disease (AD) mice are treats with Se-Methylselenocysteine (0.75 mg/kg BW per day) in their drinking water for 10 months. Se-Methylselenocysteine reduces oxidative stress and neuro-inflammation; Se-Methylselenocysteine modulates the distribution and levels of several metal ions; Se-Methylselenocysteine decreases amyloid-β peptide (Aβ) generation by inhibiting the expression of its precursor protein APP and β-secretase (BACE1), and attenuates tau hyperphosphorylation and neurofibrillary tangles (NFT) formation via promoting protein phosphatase 2A (PP2A) activity, thereby preserving synaptic proteins and neuron activities and finally improving spatial learning and memory deficits in AD model mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female athymic nude mice (bearing human A253 and FaDu squamous cell carcinoma xenografts)^[2]
Dosage:

0.2 mg/mouse
Administration:

p.o.; daily for 14 days (7 days before and 7 days after Cyclophosphamide or CDDP in a total of 14 days)
Result:

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 26046-90-2
Appearance Solid
Molecular Weight 182.08
Formula C₄H₉NO₂Se
Color White to off-white
SMILES

OC([C@@H](N)C[Se]C)=O
Synonyms

Methylselenocysteine; Se-Methylseleno-L-cysteine
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Plants
- other families
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Redox Biol

Pharmacological activation of GPX4 ameliorates doxorubicin-induced cardiomyopathy. [Abstract]

2024 Apr:70:103024. PMID: 38232458
Cell Mol Life Sci

Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc. [Abstract]

2024 Jan 22;81(1):49. PMID: 38252317

Se-Methylselenocysteine purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2024 Jan 22;81(1):49. [Abstract]

qPCR and Western blotting revealed that high strain loading reduced the GPX4 mRNA and protein level while Se-Met (2 mg/L, Se-Methylselenocysteine) supplementation promoted GPX4 expression.

Se-Methylselenocysteine purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2024 Jan 22;81(1):49. [Abstract]

The results of Immunofluorescence for Col-2 suggested that Se-Met (2 mg/mL, Se-Methylselenocysteine) supplementation promoted the expression of Col-2 but ML210 restricted this effect.

Solvent & Solubility

In Vitro:

H₂O : 62.5 mg/mL (343.26 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.4921 mL

27.4605 mL

54.9209 mL

5 mM

1.0984 mL

5.4921 mL

10.9842 mL

10 mM

0.5492 mL

2.7460 mL

5.4921 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 50 mg/mL (274.60 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (788 KB)
- English - EN (788 KB)
- Français - FR (788 KB)
- Deutsch - DE (788 KB)
- Norwegian - NO (788 KB)
- Español - ES (788 KB)
- Swedish - SV (788 KB)
- Italian - IT (788 KB)
- Korean - KR (788 KB)
- Portuguese - PT (788 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92. [Content Brief]

[2]. Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43. [Content Brief]

[3]. Xie Y, et al. Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 2018 Jun;62(12):e1800107. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	5.4921 mL	27.4605 mL	54.9209 mL	137.3023 mL
	5 mM	1.0984 mL	5.4921 mL	10.9842 mL	27.4605 mL
	10 mM	0.5492 mL	2.7460 mL	5.4921 mL	13.7302 mL
	15 mM	0.3661 mL	1.8307 mL	3.6614 mL	9.1535 mL
	20 mM	0.2746 mL	1.3730 mL	2.7460 mL	6.8651 mL
	25 mM	0.2197 mL	1.0984 mL	2.1968 mL	5.4921 mL
	30 mM	0.1831 mL	0.9153 mL	1.8307 mL	4.5767 mL
	40 mM	0.1373 mL	0.6865 mL	1.3730 mL	3.4326 mL
	50 mM	0.1098 mL	0.5492 mL	1.0984 mL	2.7460 mL
	60 mM	0.0915 mL	0.4577 mL	0.9153 mL	2.2884 mL
	80 mM	0.0687 mL	0.3433 mL	0.6865 mL	1.7163 mL
	100 mM	0.0549 mL	0.2746 mL	0.5492 mL	1.3730 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Se-Methylselenocysteine

2 Cited Publications

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Se-Methylselenocysteine

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Publications Citing Use of MedChemExpress (MCE) Se-Methylselenocysteine

All Endogenous Metabolite Isoforms

All Beta-secretase Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Se-Methylselenocysteine Related Classifications

HY-114245 Related Classifications