1. Anti-infection
    Autophagy
  2. HIV
    Autophagy

Ebselen (Synonyms: SPI-1005; PZ-51; CCG-39161)

Cat. No.: HY-13750 Purity: 99.89%
Handling Instructions

Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication.

For research use only. We do not sell to patients.

Ebselen Chemical Structure

Ebselen Chemical Structure

CAS No. : 60940-34-3

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5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
50 mg USD 168 In-stock
Estimated Time of Arrival: December 31
100 mg USD 288 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Customer Validation

    Ebselen purchased from MCE. Usage Cited in: Exp Ther Med. 2018 Dec.

    Ebselen influences the expression of apoptosis‑related proteins. The effects of ebselen on C‑Caspase‑8, C‑Caspase‑3, Bax, Bcl‑2 and C‑PARP are analyzed by western blotting.
    • Biological Activity

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    • References

    Description

    Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication. Target: Ebselen is an organoselenium compound, as an inhibitor of HIV-1 capsid CTD dimerization. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. [1] Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen is an inhibitor of inositol monophosphatase (IMPase). Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. [2]

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6472 mL 18.2362 mL 36.4724 mL
    5 mM 0.7294 mL 3.6472 mL 7.2945 mL
    10 mM 0.3647 mL 1.8236 mL 3.6472 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    274.18

    Formula

    C₁₃H₉NOSe

    CAS No.

    60940-34-3

    SMILES

    O=C1N(C2=CC=CC=C2)[Se]C3=C1C=CC=C3

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.89%

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Product Name:
    Ebselen
    Cat. No.:
    HY-13750
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    Ebselen

    Cat. No.: HY-13750