1. Neuronal Signaling
    Membrane Transporter/Ion Channel
    Anti-infection
    Metabolic Enzyme/Protease
  2. Calcium Channel
    Virus Protease
    HIV
    Phosphatase
  3. Ebselen

Ebselen (Synonyms: SPI-1005; PZ-51; CCG-39161)

Cat. No.: HY-13750 Purity: 99.58%
Handling Instructions

Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker. Ebselen potently inhibits Mpro (IC50=0.67 μM) and COVID-19 virus (EC50=4.67 μM).Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity.

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Ebselen Chemical Structure

Ebselen Chemical Structure

CAS No. : 60940-34-3

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10 mM * 1  mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
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10 mg USD 84 In-stock
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50 mg USD 168 In-stock
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100 mg USD 288 In-stock
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Customer Review

Based on 6 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Ebselen purchased from MCE. Usage Cited in: Exp Ther Med. 2019 Feb;17(2):1412-1419.

    Ebselen influences the expression of apoptosis‑related proteins. The effects of ebselen on C‑Caspase‑8, C‑Caspase‑3, Bax, Bcl‑2 and C‑PARP are analyzed by western blotting.
    • Biological Activity

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    • Customer Review

    Description

    Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker[1][2]. Ebselen potently inhibits Mpro (IC50=0.67 μM) and COVID-19 virus (EC50=4.67 μM)[3].Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity[4][5].

    IC50 & Target

    IC50: 0.67 μM (Mpro)[3]
    EC50: 4.67 μM (COVID-19 virus)[3]

    In Vitro

    Ebselen (SPI-1005; 0.4-100 μM; 20-24 hours) shows strong antiviral effects at a concentration of 10 μM treatment in COVID-19 virus infected Vero cells. Ebsele covalently binds to C145 of the catalytic dyad in COVID-19 virus Mpro[3].
    Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process[4].
    Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. Ebselen inhibits inositol monophosphatase (IMPase)[5].
    Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic, renal cancer cell lines[6].

    RT-PCR[3]

    Cell Line: COVID-19 virus infected Vero cells
    Concentration: 0.4, 1.2, 3.7, 11.1, 33.3, 100 μM
    Incubation Time: 20-24 hours
    Result: Showed strong antiviral effects at a concentration of 10 μM treatment.
    In Vivo

    Ebselen (5, 10 mg/kg; IP) decreases 5-HT2 agonist-induced head twitches in a dose-dependent manner[5].

    Animal Model: 20-25 g 10-12 week old male C57Bl6 mice[5]
    Dosage: 5, 10 mg/kg
    Administration: IP
    Result: Decreased 5-HT2 agonist-induced head twitches in a dose-dependent manner.
    Clinical Trial
    Molecular Weight

    274.18

    Formula

    C₁₃H₉NOSe

    CAS No.

    60940-34-3

    SMILES

    O=C1N(C2=CC=CC=C2)[Se]C3=C1C=CC=C3

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (182.36 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6472 mL 18.2362 mL 36.4724 mL
    5 mM 0.7294 mL 3.6472 mL 7.2945 mL
    10 mM 0.3647 mL 1.8236 mL 3.6472 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (9.12 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (9.12 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.58%

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    Keywords:

    EbselenSPI-1005PZ-51CCG-39161SPI1005SPI 1005PZ51PZ 51CCG39161CCG 39161Calcium ChannelVirus ProteaseHIVPhosphataseCa2+ channelsCa channelsHuman immunodeficiency virusblood-brainbarrierQSOX1glutathioneperoxidasemimeticvoltage-dependentVDCCMproCOVID-19C145inositolmonophosphataseIMPaseInhibitorinhibitorinhibit

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