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  3. Ebselen

Ebselen (Synonyms: SPI-1005; PZ-51; CCG-39161)

Cat. No.: HY-13750 Purity: 99.58%
Handling Instructions

Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication.

For research use only. We do not sell to patients.

Ebselen Chemical Structure

Ebselen Chemical Structure

CAS No. : 60940-34-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
50 mg USD 168 In-stock
Estimated Time of Arrival: December 31
100 mg USD 288 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Ebselen purchased from MCE. Usage Cited in: Exp Ther Med. 2019 Feb;17(2):1412-1419.

    Ebselen influences the expression of apoptosis‑related proteins. The effects of ebselen on C‑Caspase‑8, C‑Caspase‑3, Bax, Bcl‑2 and C‑PARP are analyzed by western blotting.
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    • Customer Review

    Description

    Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication. Target: Ebselen is an organoselenium compound, as an inhibitor of HIV-1 capsid CTD dimerization. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. [1] Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen is an inhibitor of inositol monophosphatase (IMPase). Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. [2]

    Clinical Trial
    Molecular Weight

    274.18

    Formula

    C₁₃H₉NOSe

    CAS No.

    60940-34-3

    SMILES

    O=C1N(C2=CC=CC=C2)[Se]C3=C1C=CC=C3

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (182.36 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6472 mL 18.2362 mL 36.4724 mL
    5 mM 0.7294 mL 3.6472 mL 7.2945 mL
    10 mM 0.3647 mL 1.8236 mL 3.6472 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (9.12 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (9.12 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.58%

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    Ebselen
    Cat. No.:
    HY-13750
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