L-SelenoMethionine
Based on 5 publication(s) in Google Scholar
L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.79%
- CAS. Nr.: 3211-76-5
- Formel: C5H11NO2Se
- Molecular Weight:196.11
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-SelenoMethionine
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Customer Validation & Images
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Cell Imaging/Staining
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Cell Imaging/Staining
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Bio/Physico-chemical Assay
Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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Microbial Metabolite |
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Cell Line
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Type | Value | Description | References |
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| A549 | IC50 |
65 μM
Compound: 3
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Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 6 days by SRB assay
Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 6 days by SRB assay
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[PMID: 34217061] |
| DU-145 | IC50 |
40 μM
Compound: 3
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Anticancer activity against human DU-145 cells assessed as cell growth inhibition measured after 6 days by SRB assay
Anticancer activity against human DU-145 cells assessed as cell growth inhibition measured after 6 days by SRB assay
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[PMID: 34217061] |
| HT-29 | IC50 |
130 μM
Compound: 3
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Anticancer activity against human HT-29 cells assessed as cell growth inhibition measured after 6 days by SRB assay
Anticancer activity against human HT-29 cells assessed as cell growth inhibition measured after 6 days by SRB assay
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[PMID: 34217061] |
| UACC-375 | IC50 |
50 μM
Compound: 3
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Anticancer activity against human UACC-375 cells assessed as cell growth inhibition measured after 6 days by SRB assay
Anticancer activity against human UACC-375 cells assessed as cell growth inhibition measured after 6 days by SRB assay
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[PMID: 34217061] |
| V79 | IC50 |
267 μM
Compound: L-selenomethionine
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Cytotoxicity activity against V79 cells
Cytotoxicity activity against V79 cells
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[PMID: 12852761] |
L-SelenoMethionine (1-500 μM; 24-72 h) is selectively inhibits the growth of prostate cancer cells, compared with normal cells[2].
L-SelenoMethionine (500 μM; 48 h) induce apoptosis in prostate cancer cells[2].
L-SelenoMethionine (500 μM; 48 h) causes an increase in arrest in the G2-M phase of the cell cycle selectively in prostate cancer cells[2].
L-SelenoMethionine (5 μM; 24 h) mitigates gene expression associated with the cellular stress response from 10 cGy irradiation[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
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Concentration:1, 5, 10, 50, 100, 500 μM
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Incubation Time:24, 48, 72 hours
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Result:Inhibited the growth of prostate cancer cells, with a lower IC50 (1-90 μM) at 72 h than normal prostate cells (>500 μM).
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Cell Line:Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
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Concentration:500 μM
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Incubation Time:48 hours
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Result:Exhibited the highest level of DNA condensation in androgen-responsive LNCaP carcinoma cells, followed by PC-3 and DU145 cells.
Exhibited the nicked-end DNA labeling in prostate cancer cells.
Promoted the PARP cleavage in prostate cancer cells.
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Cell Line:Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
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Concentration:500 μM
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Incubation Time:48 hours
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Result:Increased the sub-G0-G1 cell fraction of LNCaP (41.5%), PC-3 (12.1%), and DU145 cells (11.2%).
Caused a significant increases in G2 cells , particularly in LNCaP (13%), PC-3 (32%), and DU145 (20%) cells.
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Cell Line:Human thyroid epithelial cells (HTori-3)
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Concentration:5 μM
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Incubation Time:24 hours
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Result:Downregulated the CDC6, GADD45A, FAS and ATF3 in irradiated cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 3211-76-5
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Appearance Solid
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Molecular Weight 196.11
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Formel C5H11NO2Se
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Color White to off-white
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SMILES
O=C(O)[C@@H](N)CC[Se]C
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Synonyms
L-SeMet
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (5)
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Journal Impact Factor
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Most Recent
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Bioact Mater
Supramolecular self-assembly of EGCG-selenomethionine nanodrug for treating osteoarthritis. [Abstract]2023 Oct 7:32:164-176. PMID: 37822916 -
Antioxidants (Basel)
L-Selenomethionine Alleviates Cryo-Induced Ferroptosis Through the NRF2-SLC7A11-GPX4 Pathway, Improving Post-Thaw In Vitro Quality of Dairy Goat Spermatozoa. [Abstract]2026 Mar 20;15(3):392. PMID: 41897537
L-SelenoMethionine purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2026 Mar 20;15(3):392. [Abstract]
Quantitative analysis showing that plasma membrane integrity was significantly higher in the 4, 6, and 8 μM L-SeMet (L-SelenoMethionine) groups than in the control (p < 0.05), with the greatest improvement observed at 6 μM.
L-SelenoMethionine purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2026 Mar 20;15(3):392. [Abstract]
Quantitative analysis showing that acrosome integrity was significantly improved in the 6 μM L-SeMet (L-SelenoMethionine) group compared with the control (p < 0.05).
L-SelenoMethionine purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2026 Mar 20;15(3):392. [Abstract]
Principal component analysis (PCA) showing distinct clustering between the control and L-SeMet (L-SelenoMethionine) groups, indicating clear separation of global protein expression profiles.
L-SelenoMethionine purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2026 Mar 20;15(3):392. [Abstract]
Spermatozoa treated with 6 μM L-SeMet (L-SelenoMethionine) showing improved mitochondrial morphology, characterized by preserved double membranes, dense matrix, and clearly defined cristae.
L-SelenoMethionine purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2026 Mar 20;15(3):392. [Abstract]
Superoxide dismutase (SOD) activity increased significantly at 4, 6, 8, and 10 μM (p < 0.05), and glutathione (GSH) concentrations were higher in all L-SeMet (L-SelenoMethionine)-treated groups (2–10 μM) than in the control (p < 0.05).
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J Biochem Mol Toxicol
p38MAPK/HSPB1 is involved in the regulatory effects of selenomethionine on the apoptosis, viability and testosterone secretion of sheep Leydig cells exposed to heat. [Abstract]2024 Sep;38(9):e23826. PMID: 39188067 -
Lösungsmittel & Löslichkeit
H2O : 14.29 mg/mL (72.87 mM; Need ultrasonic)
DMSO : 1 mg/mL (5.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 9.09 mg/mL (46.35 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (789 KB)
- English - EN (789 KB)
- Français - FR (789 KB)
- Deutsch - DE (789 KB)
- Norwegian - NO (789 KB)
- Español - ES (789 KB)
- Swedish - SV (789 KB)
- Italian - IT (789 KB)
- Korean - KR (789 KB)
- Portuguese - PT (789 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Schrauzer GN, et, al. Selenomethionine: a review of its nutritional significance, metabolism and toxicity. J Nutr. 2000 Jul;130(7):1653-6. [Content Brief]
[2]. Menter DG, et, al. Selenium effects on prostate cell growth. Cancer Epidemiol Biomarkers Prev. 2000 Nov;9(11):1171-82. [Content Brief]
[3]. Jornot L, et, al. Differential regulation of glutathione peroxidase by selenomethionine and hyperoxia in endothelial cells. Biochem J. 1995 Mar 1;306 ( Pt 2)(Pt 2):581-7. [Content Brief]
[4]. Nuth M, et, al. Mitigating effects of L-selenomethionine on low-dose iron ion radiation-induced changes in gene expression associated with cellular stress. Oncol Lett. 2013 Jul;6(1):35-42. [Content Brief]
[5]. Guan J, et, al. Effects of dietary supplements on space radiation-induced oxidative stress in Sprague-Dawley rats. Radiat Res. 2004 Nov;162(5):572-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 5.0992 mL | 25.4959 mL | 50.9918 mL | 127.4795 mL |
| 5 mM | 1.0198 mL | 5.0992 mL | 10.1984 mL | 25.4959 mL | |
| H2O | 10 mM | 0.5099 mL | 2.5496 mL | 5.0992 mL | 12.7479 mL |
| 15 mM | 0.3399 mL | 1.6997 mL | 3.3995 mL | 8.4986 mL | |
| 20 mM | 0.2550 mL | 1.2748 mL | 2.5496 mL | 6.3740 mL | |
| 25 mM | 0.2040 mL | 1.0198 mL | 2.0397 mL | 5.0992 mL | |
| 30 mM | 0.1700 mL | 0.8499 mL | 1.6997 mL | 4.2493 mL | |
| 40 mM | 0.1275 mL | 0.6374 mL | 1.2748 mL | 3.1870 mL | |
| 50 mM | 0.1020 mL | 0.5099 mL | 1.0198 mL | 2.5496 mL | |
| 60 mM | 0.0850 mL | 0.4249 mL | 0.8499 mL | 2.1247 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-SelenoMethionine Related Classifications
HY-B1000A Related Classifications
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