1. Metabolic Enzyme/Protease
    Apoptosis
  2. Endogenous Metabolite
    Apoptosis
  3. L-SelenoMethionine

L-SelenoMethionine 

Cat. No.: HY-B1000A Purity: 99.84%
Handling Instructions

L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase.

For research use only. We do not sell to patients.

L-SelenoMethionine Chemical Structure

L-SelenoMethionine Chemical Structure

CAS No. : 3211-76-5

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10 mM * 1 mL in Water USD 79 In-stock
Estimated Time of Arrival: December 31
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Description

L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

L-SelenoMethionine (1-500 μM; 24-72 h) is selectively inhibits the growth of prostate cancer cells, compared with normal cells[2].
L-SelenoMethionine (500 μM; 48 h) induce apoptosis in prostate cancer cells[2].
L-SelenoMethionine (500 μM; 48 h) causes an increase in arrest in the G2-M phase of the cell cycle selectively in prostate cancer cells[2].
L-SelenoMethionine (5 μM; 24 h) mitigates gene expression associated with the cellular stress response from 10 cGy irradiation[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration: 1, 5, 10, 50, 100, 500 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibited the growth of prostate cancer cells, with a lower IC50 (1-90 μM) at 72 h than normal prostate cells (>500 μM).

Apoptosis Analysis[2]

Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration: 500 μM
Incubation Time: 48 hours
Result: Exhibited the highest level of DNA condensation in androgen-responsive LNCaP carcinoma cells, followed by PC-3 and DU145 cells.
Exhibited the nicked-end DNA labeling in prostate cancer cells.
Promoted the PARP cleavage in prostate cancer cells.

Cell Cycle Analysis[2]

Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration: 500 μM
Incubation Time: 48 hours
Result: Increased the sub-G0-G1 cell fraction of LNCaP (41.5%), PC-3 (12.1%), and DU145 cells (11.2%).
Caused a significant increases in G2 cells , particularly in LNCaP (13%), PC-3 (32%), and DU145 (20%) cells.

RT-PCR[3]

Cell Line: Human thyroid epithelial cells (HTori-3)
Concentration: 5 μM
Incubation Time: 24 hours
Result: Downregulated the CDC6, GADD45A, FAS and ATF3 in irradiated cells.
In Vivo

L-SelenoMethionine (0.06-12 μg/g diet; p.o. for 3 d) partially or completely prevent the decrease in the serum or plasma levels of total antioxidants in rats exposed to gamma rays, protons or HZE particles[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

196.11

Formula

C5H11NO2Se

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 14.29 mg/mL (72.87 mM; Need ultrasonic)

DMSO : 1 mg/mL (5.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0992 mL 25.4959 mL 50.9918 mL
5 mM 1.0198 mL 5.0992 mL 10.1984 mL
10 mM 0.5099 mL 2.5496 mL 5.0992 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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L-SelenoMethionine
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