L-Selenocystine
Based on 2 publication(s) in Google Scholar
L-Selenocystine is a selenium-containing amino acid. L-Selenocystine has redox properties. L-Selenocystine is cytotoxic to various tumor cells and can induce the production of ROS and apoptosis. L-Selenocystine can block the Nrf2 and autophagy pathways. L-Selenocystine has anti-tumor activity.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 29621-88-3
- Formula: C6H12N2O4Se2
- Molecular Weight:334.09
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-Selenocystine
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
3.6 μM
Compound: 1
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Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 34217061] |
| CNE-2 | IC50 |
5.6 μM
Compound: 1
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Anticancer activity against human CNE-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anticancer activity against human CNE-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 34217061] |
| HL-60 | IC50 |
34.5 μM
Compound: 1
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Anticancer activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anticancer activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 34217061] |
| SW-620 | IC50 |
7.3 μM
Compound: 1
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Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 34217061] |
L-Selenocystine (8-32 μM; 24 h) can inhibit the proliferation of HepG2 cells (IC50: 5.444 μM) and induce the production of ROS and apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2
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Concentration:8, 16, 32 μM
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Incubation Time:24 h
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Result:Significantly inhibited HepG2 cell growth with increasing concentration.
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Cell Line:HepG2
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Concentration:8, 16, 32 μM
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Incubation Time:/
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Result:Inhibited the levels of Bid, Bax, Cleaved Caspase-9, Cleaved Caspase-3 and Cleaved PARP.
Reduced the levels of Bcl2.
Chemical Information
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CAS No. 29621-88-3
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Appearance Solid
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Molecular Weight 334.09
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Formula C6H12N2O4Se2
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Color Light brown to yellow
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
Selenomethionine as a dual-mechanism ferroptosis inhibitor: selenium-supply-driven GPX4 biosynthesis beyond transsulfuration and reductive-capacity-mediated ROS scavenging independent of GPX4 activity. [Abstract]2026 Feb 14;17(1):224. PMID: 41688429 -
J Colloid Interface Sci
Thermosensitive hydrogel with antioxidant and photothermal antibacterial effects accelerates healing of bacterial-inflamed maxillofacial wounds. [Abstract]2026 Feb 15;704(Pt 1):139366. PMID: 41197459
Solvent & Solubility
H2O : 5.88 mg/mL (17.60 mM; ultrasonic and warming and adjust pH to 1 with HCl and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (789 KB)
- English - EN (789 KB)
- Français - FR (789 KB)
- Deutsch - DE (789 KB)
- Norwegian - NO (789 KB)
- Español - ES (789 KB)
- Swedish - SV (789 KB)
- Italian - IT (789 KB)
- Korean - KR (789 KB)
- Portuguese - PT (789 KB)
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Handling Instructions (2659 KB)
References
[2]. Hsu WL, et al. Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis. Cell Death Dis. 2022 Dec 20;13(12):1060. [Content Brief]
[3]. Michio Iwaoka, et al. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008 Mar;5(3):359-74.Michio Iwaoka, et al. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008 Mar;5(3):359-74. [Content Brief]
[4]. Roy J, et al. Optically active selenium-containing amino acids. The synthesis of L-selenocystine and L-selenolanthionine. J Org Chem. 1970 Feb;35(2):510-3. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.9932 mL | 14.9660 mL | 29.9321 mL | 74.8301 mL |
| 5 mM | 0.5986 mL | 2.9932 mL | 5.9864 mL | 14.9660 mL | |
| 10 mM | 0.2993 mL | 1.4966 mL | 2.9932 mL | 7.4830 mL | |
| 15 mM | 0.1995 mL | 0.9977 mL | 1.9955 mL | 4.9887 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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