29621-88-3
29621-88-3
Chemical Structure
L-Selenocystine
- CAS No.: 29621-88-3
- Formula:C6H12N2O4Se2
- Molecular Weight:334.09
IUPAC Name: (2R,2'R)-3,3'-diselanediylbis(2-aminopropanoic acid)
InChIKey: JULROCUWKLNBSN-IMJSIDKUSA-N
SMILES: N[C@@H](C[Se][Se]C[C@@H](C(O)=O)N)C(O)=O
Biological Activity: L-Selenocystine is a selenium-containing amino acid. L-Selenocystine has redox properties. L-Selenocystine is cytotoxic to various tumor cells and can induce the production of ROS and apoptosis. L-Selenocystine can block the Nrf2 and autophagy pathways. L-Selenocystine has anti-tumor activity[1][2][3][4].
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L-Selenocystine | 98.0% | L-Selenocystine is a selenium-containing amino acid. L-Selenocystine has redox properties. L-Selenocystine is cytotoxic to various tumor cells and can induce the production of ROS and apoptosis. L-Selenocystine can block the Nrf2 and autophagy pathways. L-Selenocystine has anti-tumor activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-113064Selenocystine -
Similarity Score 0.87
HY-180740L-Selenocystathionine -
Similarity Score 0.83
HY-128746R2,6-Diaminoheptanedioic acid (Standard) -
Similarity Score 0.83
HY-W334800S(2S,6S)-2,6-Diaminoheptanedioic acid-13C7,15N2 -
Similarity Score 0.83
HY-W476434meso-2,6-Diaminopimelic acid -
Similarity Score 0.83
HY-W7536712,6-Diaminoheptanedioic acid-13C7 -
Similarity Score 0.76
HY-101310RSYM 2081 (Standard) -
Similarity Score 0.76
HY-100805S2D-Glutamic acid-13C5 -
Similarity Score 0.76
HY-14608SL-Glutamic acid-13C -
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References
- [1]. CHEN H, et al. L-Selenocystine induce HepG2 cells apoptosis through ROS-mediated signaling pathways. Biocell, 2022, 46(10).
- [2]. Hsu WL, et al. Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis. Cell Death Dis. 2022 Dec 20;13(12):1060. [Content Brief]
- [3]. Michio Iwaoka, et al. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008 Mar;5(3):359-74.Michio Iwaoka, et al. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008 Mar;5(3):359-74. [Content Brief]
- [4]. Roy J, et al. Optically active selenium-containing amino acids. The synthesis of L-selenocystine and L-selenolanthionine. J Org Chem. 1970 Feb;35(2):510-3. [Content Brief]
