Selenomethionine
Based on 11 publication(s) in Google Scholar
Selenomethionine is a naturally occurring amino acid containing selenium that has oral activity and is a common natural food source. Selenomethionine has antitumor activity.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 1464-42-2
- Formula: C5H11NO2Se
- Molecular Weight:196.11
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Selenomethionine
More- Redox Biol. 2024 Apr:70:103024. [Abstract]
- Cell Death Dis. 2026 Feb 14;17(1):224. [Abstract]
- Free Radic Biol Med. 2025 Dec 31:245:283-300. [Abstract]
- Free Radic Biol Med. 2023 Aug 20:205:291-304. [Abstract]
- Phytother Res. 2025 Nov 6. [Abstract]
- Front Immunol. 2023 Jul 20:14:1171150. [Abstract]
- Biochem Pharmacol. 2026 Jun:248:117816. [Abstract]
- Biochem Biophys Res Commun. 2025 Nov 27:794:153066. [Abstract]
- Biochem Biophys Res Commun. 2025 Sep 8:778:152398. [Abstract]
- Orthop Surg. 2025 Dec;17(12):3456-3467. [Abstract]
- Oxid Med Cell Longev. 2022 Apr 11;2022:7531788. [Abstract]
Customer Validation & Images
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Others
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WB
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In Vivo Efficacy Study
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Histological Imaging/Staining
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Cell Proliferation/Viability Assay
Biological Activity
Selenomethionine (50 μM, 12 h) decreases the hatchability and glutathione consumption of Japanese rice embryos, but does not affect selenium accumulation[1].
Selenomethionine (45-135 μM, 24 h) inhibits the growth of MCF-7/S breast cancer, DU-145 prostate cancer cells and UAC-375 melanoma cells in a dose-dependent manner[2].
Selenomethionine (25-500 μM, 24 h) inhibits TBHP-induced oxidative stress and mitochondrial division by activating the Nrf2 pathway, thereby inhibiting the apoptosis of nucleus pulposus cells (NPCs) and improving intervertebral disc degeneration (IDD)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NPCs
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Concentration:25, 50, 75, 100, 150, 300, and 500 μM
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Incubation Time:24 h
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Result:Downregulated of cleaved-caspase 9, cleaved-caspase 3 and upregulated of Bax and Bcl-2.
Reduced the expression levels of DRP1, MFF, and Fis1, upregulated the expression levels of OPA1, Mfn1, and Mfn2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:IDD Rat Model[3]
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Dosage:2mg/kg/day
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Administration:i.g
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Result:Reduced NP size, collapsed disc height, significant loss of cells, and dense ECM.
Decreased the levels of Nrf2 and collagen II amd increased the expression level of MMP13.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1464-42-2
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Appearance Solid
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Molecular Weight 196.11
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Formula C5H11NO2Se
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Color White to off-white
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SMILES
O=C(O)C(N)CC[Se]C
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Synonyms
Seleno-DL-methionine; DL-Selenomethionine
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (11)
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Journal Impact Factor
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Most Recent
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Redox Biol
2024 Apr:70:103024. PMID: 38232458
Selenomethionine purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Apr:70:103024. [Abstract]
Kaplan‒Meier survival curves of mice pretreated with saline (control), SeMet (Selenomethionine), l-selenocystine, Se-methylselenocysteine, sodium selenite, and Se-rich cardamine enshiensis (0.75 mg/kg, by gavage, weekly) before DOX (20 mg/kg) administration and after the start of DOX (0.375 mg/kg, by gavage, weekly).
Selenomethionine purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Apr:70:103024. [Abstract]
A representative picric acid-Sirius red (PSR) staining image on day 28 after SeMet (Selenomethionine: 0.75 mg/kg) treatment.
Selenomethionine purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Apr:70:103024. [Abstract]
Cell viability was determined using the Cell-Quanti-Blue assay. H9C2 cells were cultured for 24 hours in medium with or without 100 nM SeMet (Selenomethionine) and then treated with DOX for 24 hours.
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Cell Death Dis
Selenomethionine as a dual-mechanism ferroptosis inhibitor: selenium-supply-driven GPX4 biosynthesis beyond transsulfuration and reductive-capacity-mediated ROS scavenging independent of GPX4 activity. [Abstract]2026 Feb 14;17(1):224. PMID: 41688429
Selenomethionine purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 14;17(1):224. [Abstract]
HT1080 and OS-RC-2 cells were treated with RSL3 (2 μM) or selenomethionine (SeleMet) (100 μM) as indicated for 4–6 h (n = 3). The lipid ROS levels were determined using flow cytometry (HT1080 and OS-RC-2 for 4 h)
Selenomethionine purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 14;17(1):224. [Abstract]
The protein levels of the GPX4 in OS-RC-2, HepG2, and HT1080 cells are cultured in ± CC (cystine) medium treated with Selenomethionine (SeleMet) were measured by western blot (WB).
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Free Radic Biol Med
rhBNP inhibited ferroptosis in renal ischemia-reperfusion injury through promoting selenium recycling. [Abstract]2025 Dec 31:245:283-300. PMID: 41482081 -
Free Radic Biol Med
PM2.5 contributed to pulmonary epithelial senescence and ferroptosis by regulating USP3-SIRT3-P53 axis. [Abstract]2023 Aug 20:205:291-304. PMID: 37348684 -
Phytother Res
Exploring the Potential Targets and Molecular Mechanisms of Selenomethionine to Attenuate Acute Kidney Injury Based on Network Pharmacology, Molecular Simulation Technology and Animal Experiments. [Abstract]2025 Nov 6. PMID: 41196193 -
Front Immunol
Selenomethionine against titanium particle-induced osteolysis by regulating the ROS-dependent NLRP3 inflammasome activation via the β-catenin signaling pathway. [Abstract]2023 Jul 20:14:1171150. PMID: 37545495 -
Biochem Pharmacol
Pharmacological activation of GPX4 by selenomethionine attenuates cisplatin-induced ototoxicity and hearing loss. [Abstract]2026 Jun:248:117816. PMID: 41698483 -
Biochem Biophys Res Commun
2025 Nov 27:794:153066. PMID: 41313944 -
Biochem Biophys Res Commun
Selenomethionine activates MAPK signaling to activate epidermal keratinocyte migration, speeding skin wound healing. [Abstract]2025 Sep 8:778:152398. PMID: 40706245 -
Orthop Surg
Selenium Attenuates Dexamethasone-Induced Osteoblast Dysfunction and Prevents Femoral Head Osteonecrosis via PI3K/AKT/GSK3β Pathway Activation. [Abstract]2025 Dec;17(12):3456-3467. PMID: 41253602 -
Oxid Med Cell Longev
Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2. [Abstract]2022 Apr 11;2022:7531788. PMID: 35450408
Solvent & Solubility
H2O : 12.5 mg/mL (63.74 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 10 mg/mL (50.99 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Purity & Documentation
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Data Sheet (274 KB)
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SDS (729 KB)
- English - EN (729 KB)
- Français - FR (729 KB)
- Deutsch - DE (729 KB)
- Norwegian - NO (729 KB)
- Español - ES (729 KB)
- Swedish - SV (729 KB)
- Italian - IT (729 KB)
- Korean - KR (729 KB)
- Portuguese - PT (729 KB)
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Handling Instructions (2659 KB)
References
[1]. Kupsco A, et al. Mechanisms of selenomethionine developmental toxicity and the impacts of combined hypersaline conditions on Japanese medaka (Oryzias latipes). Environ Sci Technol. 2014 Jun 17;48(12):7062-8. [Content Brief]
[2]. Redman C, et al. Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines. Cancer Lett. 1998 Mar 13;125(1-2):103-10. [Content Brief]
[3]. Wang P, et al. Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2. Oxid Med Cell Longev. 2022 Apr 11;2022:7531788. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 5.0992 mL | 25.4962 mL | 50.9923 mL | 127.4808 mL |
| 5 mM | 1.0198 mL | 5.0992 mL | 10.1985 mL | 25.4962 mL | |
| 10 mM | 0.5099 mL | 2.5496 mL | 5.0992 mL | 12.7481 mL | |
| 15 mM | 0.3399 mL | 1.6997 mL | 3.3995 mL | 8.4987 mL | |
| 20 mM | 0.2550 mL | 1.2748 mL | 2.5496 mL | 6.3740 mL | |
| 25 mM | 0.2040 mL | 1.0198 mL | 2.0397 mL | 5.0992 mL | |
| 30 mM | 0.1700 mL | 0.8499 mL | 1.6997 mL | 4.2494 mL | |
| 40 mM | 0.1275 mL | 0.6374 mL | 1.2748 mL | 3.1870 mL | |
| 50 mM | 0.1020 mL | 0.5099 mL | 1.0198 mL | 2.5496 mL | |
| 60 mM | 0.0850 mL | 0.4249 mL | 0.8499 mL | 2.1247 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Selenomethionine Related Classifications
HY-B1000 Related Classifications
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