Se-Methylselenocysteine hydrochloride
Based on 2 publication(s) in Google Scholar
Se-Methylselenocysteine hydrochloride, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine hydrochloride is orally bioavailable, and induces apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 863394-07-4
- Formula: C4H10ClNO2Se
- Molecular Weight:218.54
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Se-Methylselenocysteine hydrochloride
More
Customer Validation & Images
-
WB
-
IHC
All Endogenous Metabolite Isoforms
More
Biological Activity
Se-Methylselenocysteine hydrochloride (100-400 μM; 3 days) induces apoptosis in SKOV-33 cells[1].
?
Se-Methylselenocysteine hydrochloride (100-400 μM; 3 days) induces caspase-3 mediated apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
? Alzheimer's disease (AD) mice are treats with Se-Methylselenocysteine hydrochloride (0.75 mg/kg BW per day) in their drinking water for 10 months. Se-Methylselenocysteine hydrochloride reduces oxidative stress and neuro-inflammation; Se-Methylselenocysteine hydrochloride modulates the distribution and levels of several metal ions; Se-Methylselenocysteine hydrochloride decreases amyloid-β peptide (Aβ) generation by inhibiting the expression of its precursor protein APP and β-secretase (BACE1), and attenuates tau hyperphosphorylation and neurofibrillary tangles (NFT) formation via promoting protein phosphatase 2A (PP2A) activity, thereby preserving synaptic proteins and neuron activities and finally improving spatial learning and memory deficits in AD model mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 863394-07-4
-
Molecular Weight 218.54
-
Formula C4H10ClNO2Se
-
SMILES
C[Se]C[C@H](N)C(O)=O.Cl
-
Synonyms
Methylselenocysteine hydrochloride; Se-Methylseleno-L-cysteine hydrochloride
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Redox Biol
2024 Apr:70:103024. PMID: 38232458 -
Cell Mol Life Sci
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc. [Abstract]2024 Jan 22;81(1):49. PMID: 38252317
Se-Methylselenocysteine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2024 Jan 22;81(1):49. [Abstract]
qPCR and Western blotting revealed that high strain loading reduced the GPX4 mRNA and protein level while Se-Met (2 mg/L, Se-Methylselenocysteine) supplementation promoted GPX4 expression.
Se-Methylselenocysteine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2024 Jan 22;81(1):49. [Abstract]
The results of Immunofluorescence for Col-2 suggested that Se-Met (2 mg/mL, Se-Methylselenocysteine) supplementation promoted the expression of Col-2 but ML210 restricted this effect.
Purity & Documentation
References
[1]. Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92. [Content Brief]
[2]. Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43. [Content Brief]
[3]. Xie Y, et al. Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 2018 Jun;62(12):e1800107. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Se-Methylselenocysteine hydrochloride Related Classifications
HY-114245B Related Classifications
Powered by Bioz