1. Neuronal Signaling
  2. Beta-secretase

AZD3839 free base 

Cat. No.: HY-13438 Purity: 99.89%
Handling Instructions

AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.

For research use only. We do not sell to patients.
AZD3839 free base Chemical Structure

AZD3839 free base Chemical Structure

CAS No. : 1227163-84-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 172 In-stock
5 mg USD 156 In-stock
10 mg USD 240 In-stock
25 mg USD 480 In-stock
50 mg USD 840 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor. target: BACE1, β-secretase enzyme [1] IC50: 23.6 uM [1] AZD3839 dissolved in 0.33% dimethylsulfoxide In vitro: AZD3839 and its metabolites M1 and M2 inhibited CYP3A4 in a reversible and an irreversible manner, which could affect not only the metabolism of other CYP3A4 substrates but also the metabolism of AZD3839 itself. [1] In vivo: AZD3839 is dissolved in 0.3 M gluconic acid, adjusted to pH 3. Solutions of 0.75, 2.5, and 7.5 mg/ml are prepared and are administered orally by gavage at 2 ml/kg body weight at 1.5, 5, and 15 mg/kg (study 1) and 15 mg/kg (study 2). [1]AZD3839 effectively reduces the levels of Aβ in brain, CSF, and plasma in several preclinical species. [2]

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.3180 mL 11.5899 mL 23.1798 mL
5 mM 0.4636 mL 2.3180 mL 4.6360 mL
10 mM 0.2318 mL 1.1590 mL 2.3180 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

431.41

Formula

C₂₄H₁₆F₃N₅

CAS No.

1227163-84-9

SMILES

FC1=C2C([[email protected]](C3=CC=CC(C4=CN=CN=C4)=C3)(C5=CC(C(F)F)=NC=C5)N=C2N)=CC=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
AZD3839 free base
Cat. No.:
HY-13438
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