(Rac)-AZD3839
(Rac)-AZD3839 is an orally active beta-amyloid precursor protein cleaving enzyme (BACE1) inhibitor that is blood-brain barrier-permeable. (Rac)-AZD3839 has an affinity for the human ether-a-go-go related gene (hERG) ion channel. (Rac)-AZD3839 can be used in the research of Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 1227163-56-5
- Formula: C24H15F4N5
- Molecular Weight:449.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Cerebral cortex neuron | IC50 |
436 nM
Compound: 27
|
Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISA
Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISA
|
[PMID: 22924815] |
| CHO | IC50 |
11 μM
Compound: 27
|
Inhibition of human ERG expressed in CHO cells by IonWorks assay
Inhibition of human ERG expressed in CHO cells by IonWorks assay
|
[PMID: 22924815] |
| SH-SY5Y | IC50 |
43.1 nM
Compound: 27
|
Inhibition of BACE1 in human SH-SY5Y cells assessed as inhibition of sAPPbeta release after 16 hrs by immunoassay
Inhibition of BACE1 in human SH-SY5Y cells assessed as inhibition of sAPPbeta release after 16 hrs by immunoassay
|
[PMID: 22924815] |
Chemical Information
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CAS No. 1227163-56-5
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Molecular Weight 449.40
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Formula C24H15F4N5
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SMILES
NC1=NC(C2=CC(C(F)(F)F)=NC=C2)(C3=CC=CC(C4=CN=CN=C4)=C3)C5=C1C(F)=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)