(Rac)-AZD3839
(Rac)-AZD3839 is an orally active beta-amyloid precursor protein cleaving enzyme (BACE1) inhibitor that is blood-brain barrier-permeable. (Rac)-AZD3839 has an affinity for the human ether-a-go-go related gene (hERG) ion channel. (Rac)-AZD3839 can be used in the research of Alzheimer's disease.
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- No. CAS: 1227163-56-5
- Fòrmula: C24H15F4N5
- Peso molecular:449.40
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
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HY-13240
LY2886721BACE1 Inhibitor -
HY-13438
AZD3839 free baseBACE1 Iinhibitor -
HY-16759
VerubecestatBACE1/2 Inhibitor -
HY-100740
LanabecestatBACE1 Inhibitor -
HY-10133
β-Secretase Inhibitor IVBACE-1 Inhibitor -
HY-109055
ElenbecestatBACE-1 Inhibitor -
HY-111383
LX2343Beta-secretase Inhibitor -
HY-16759A
Verubecestat TFABACE1/2 Inhibitor -
HY-10472
LY2811376BACE1 Inhibitor -
HY-16759R
Verubecestat (Standard)BACE1/2 Inhibitor -
HY-109055R
Elenbecestat (Standard)Reference Standard -
HY-100182
BACE1-IN-1BACE1/2 Inhibitor
Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Cerebral cortex neuron | IC50 |
436 nM
Compound: 27
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Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISA
Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISA
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[PMID: 22924815] |
| CHO | IC50 |
11 μM
Compound: 27
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Inhibition of human ERG expressed in CHO cells by IonWorks assay
Inhibition of human ERG expressed in CHO cells by IonWorks assay
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[PMID: 22924815] |
| SH-SY5Y | IC50 |
43.1 nM
Compound: 27
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Inhibition of BACE1 in human SH-SY5Y cells assessed as inhibition of sAPPbeta release after 16 hrs by immunoassay
Inhibition of BACE1 in human SH-SY5Y cells assessed as inhibition of sAPPbeta release after 16 hrs by immunoassay
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[PMID: 22924815] |
Chemical Information
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No. CAS 1227163-56-5
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Peso molecular 449.40
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Fòrmula C24H15F4N5
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SMILES
NC1=NC(C2=CC(C(F)(F)F)=NC=C2)(C3=CC=CC(C4=CN=CN=C4)=C3)C5=C1C(F)=CC=C5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-AZD3839 Related Classifications
HY-103268 Related Classifications
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