1. Neuronal Signaling
  2. Beta-secretase
  3. Atabecestat

Atabecestat (Synonyms: JNJ-54861911)

Cat. No.: HY-109052
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Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction. Atabecestat (JNJ-54861911) is tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment.

For research use only. We do not sell to patients.

Atabecestat Chemical Structure

Atabecestat Chemical Structure

CAS No. : 1200493-78-2

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Description

Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction. Atabecestat (JNJ-54861911) is tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].

IC50 & Target

IC50: BACE1[1]

Clinical Trial
Molecular Weight

367.40

Formula

C₁₈H₁₄FN₅OS

CAS No.

1200493-78-2

SMILES

O=C(C1=NC=C(C#N)C=C1)NC2=CC=C(F)C([[email protected]@]3(C)N=C(N)SC=C3)=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AtabecestatJNJ-54861911JNJ54861911JNJ 54861911Beta-secretaseBACEβ-SecretaseBACE1CSFAlzheimerDiseaseInhibitorinhibitorinhibit

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Atabecestat
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