863394-07-4
Chemical Structure
Se-Methylselenocysteine hydrochloride
Synonym(s): Methylselenocysteine hydrochloride; Se-Methylseleno-L-cysteine hydrochloride
- CAS No.: 863394-07-4
- Formula:C4H10ClNO2Se
- Molecular Weight:218.54
IUPAC Name: 2-((4-((S)-2-(4-chloro-2-fluorophenyl)-2-methylbenzo[d][1,3]dioxol-4-yl)-3,6-dihydropyridin-1(2H)-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid
InChIKey: JMPVTFHGWJDSDV-DFWYDOINSA-N
SMILES: C[Se]C[C@H](N)C(O)=O.Cl
Biological Activity: Se-Methylselenocysteine hydrochloride, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine hydrochloride is orally bioavailable, and induces apoptosis[1][2].
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Se-Methylselenocysteine hydrochloride | Se-Methylselenocysteine hydrochloride, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine hydrochloride is orally bioavailable, and induces apoptosis. | |||||||||||||||||||||
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References
- [1]. Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92. [Content Brief]
- [2]. Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43. [Content Brief]
