1. Neuronal Signaling
  2. Beta-secretase

Verubecestat (Synonyms: MK-8931)

Cat. No.: HY-16759 Purity: 99.79%
Data Sheet SDS Handling Instructions

MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.

For research use only. We do not sell to patients.
Verubecestat Chemical Structure

Verubecestat Chemical Structure

CAS No. : 1286770-55-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $88 In-stock
5 mg $80 In-stock
10 mg $120 In-stock
25 mg $240 In-stock
50 mg $420 In-stock
100 mg $620 In-stock
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Description

MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase. target: BACE1. In vitro:MK-8931 can effectively reduce Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM. [1] Docking revealed that, with respect to their free binding energy, acylguanidine 7a has the lowest binding energy followed by MK-8931 and pioglitazone and binds significantly to β-secretase. [2]

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02910739 Merck Sharp & Dohme Corp. Amnestic Mild Cognitive Impairment|Alzheimer's Disease|Prodromal Alzheimer's Disease October 11, 2016 Phase 1
NCT01537757 Merck Sharp & Dohme Corp. Alzheimer's Disease March 2012 Phase 1
NCT01496170 Merck Sharp & Dohme Corp. Alzheimer's Disease December 2011 Phase 1
NCT01953601 Merck Sharp & Dohme Corp. Amnestic Mild Cognitive Impairment|Alzheimer's Disease|Prodromal Alzheimer's Disease November 5, 2013 Phase 3
NCT01739348 Merck Sharp & Dohme Corp. Alzheimer's Disease November 30, 2012 Phase 2|Phase 3
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.4425 mL 12.2127 mL 24.4254 mL
5 mM 0.4885 mL 2.4425 mL 4.8851 mL
10 mM 0.2443 mL 1.2213 mL 2.4425 mL
References
Molecular Weight

409.41

Formula

C₁₇H₁₇F₂N₅O₃S

CAS No.

1286770-55-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 35 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.79%

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Verubecestat
Cat. No.:
HY-16759
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