1. Neuronal Signaling
  2. Beta-secretase
  3. β-Secretase Inhibitor IV

β-Secretase Inhibitor IV (Synonyms: Axon 1125)

Cat. No.: HY-10133
Handling Instructions

β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.

For research use only. We do not sell to patients.

β-Secretase Inhibitor IV Chemical Structure

β-Secretase Inhibitor IV Chemical Structure

CAS No. : 797035-11-1

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Description

β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.

IC50 & Target

IC50: 15.3±0.6 nM (BACE-1), 230±26 nM (BACE-2), 7620±210 nM (Cathepsin D)[1]

In Vitro

In the cell culture assay, β-Secretase Inhibitor IV (Compound 2) inhibits the production of Aβ peptides with an EC50 of 43 nM. β-Secretase Inhibitor IV potently suppresses the secretion of sAPP_NF and EV40 from HEK293T cells with an IC50 near 30 nM[1].

Molecular Weight

578.72

Formula

C₃₁H₃₈N₄O₅S

CAS No.

797035-11-1

SMILES

O=S(N(C)C1=CC(C(N[[email protected]@H](CC2=CC=CC=C2)[[email protected]](O)CNC3CC3)=O)=CC(C(N[[email protected]](C)C4=CC=CC=C4)=O)=C1)(C)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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β-Secretase Inhibitor IV
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