1. Metabolic Enzyme/Protease
    Anti-infection
    Autophagy
    Apoptosis
  2. MMP
    Influenza Virus
    Autophagy
    Apoptosis
  3. Arctigenin

Arctigenin (Synonyms: (-)-Arctigenin)

Cat. No.: HY-N0035 Purity: 99.69%
Handling Instructions

Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions.

For research use only. We do not sell to patients.

Arctigenin Chemical Structure

Arctigenin Chemical Structure

CAS No. : 7770-78-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 61 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 110 In-stock
Estimated Time of Arrival: December 31
100 mg USD 154 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 7 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Arctigenin purchased from MCE. Usage Cited in: Pharmacol Res. 2020 May;155:104721.

    The Western blotting results show that incubating LA795 cells with 100 μM arctigenin led to a decrease in phospho-MEK1/2, phospho-ERK1/2 and cyclin D1 expression (n = 3).

    Arctigenin purchased from MCE. Usage Cited in: Life Sci. 2020 Sep 1;256:117983.

    The indicated cell lines are treated with 5 μM Arc (Arctigenin) for 10 h and then harvested for extraction of total cellular RNA and subsequent qRT-PCR.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions[1][2][3].

    In Vitro

    Arctigenin (0.01-1 μg/mL; 0.5-24 h) shows preferential cytotoxicity against the PANC-1 cell line under nutrient-deprived conditions in a concentration- and time-dependent manner[1].
    Arctigenin (0.01-1 μg/mL; 0.5-24 h) inhibits the survival of various cancer cell lines (ASPC-1, BXPC-3, Alexander, and PSN-1 cells) under nutrient-deprived conditions[1].
    Arctigenin (0.1-1 μg/mL; 24 h) completely inhibits Akt phosphorylation stimulated by glucose deprivation in PANC-1 cells[1].
    Arctigenin (5-25 μM) shows potent in vitro antiviral activities (IC50=2.9 μM) against influenza A virus[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Arctigenin (250 μg/mL; 0.2 mL; i.p. 6 times a week for 9 weeks) suppress the PANC-1 tumor growth in nude mice[1].
    Arctigenin (10 mg/kg; i.p. daily for 30 days) relieves experimental autoimmune encephalomyelitis (EAE) symptoms of mice[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female SPF/VAF BALB/cAn Ncrj-nu/nu mice were injected with PANC-1 cells[1]
    Dosage: 250 μg/mL, 0.2 mL
    Administration: I.p. 6 times a week for 9 weeks
    Result: Reduced the tumor weight and volume.
    No significant body weight loss was recognized.
    Clinical Trial
    Molecular Weight

    372.41

    Formula

    C21H24O6

    CAS No.
    SMILES

    O=C1OC[[email protected]](CC2=CC=C(OC)C(OC)=C2)[[email protected]]1CC3=CC=C(O)C(OC)=C3

    Structure Classification
    Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 125 mg/mL (335.65 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6852 mL 13.4261 mL 26.8521 mL
    5 mM 0.5370 mL 2.6852 mL 5.3704 mL
    10 mM 0.2685 mL 1.3426 mL 2.6852 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 6.25 mg/mL (16.78 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 6.25 mg/mL (16.78 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 6.25 mg/mL (16.78 mM); Clear solution

    *All of the co-solvents are available by MCE.
    References

    Purity: 99.69%

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    Product Name:
    Arctigenin
    Cat. No.:
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