1. Metabolic Enzyme/Protease
    Anti-infection
    Autophagy
  2. MMP
    Influenza Virus
    Autophagy
  3. Arctigenin

Arctigenin (Synonyms: (-)-Arctigenin)

Cat. No.: HY-N0035 Purity: 99.70%
Handling Instructions

Arctigenin is a lignan found in certain plants of the Asteraceae; it has shown antiviral and anticancer effects in glass; it is the aglycone of arctiin.

For research use only. We do not sell to patients.

Arctigenin Chemical Structure

Arctigenin Chemical Structure

CAS No. : 7770-78-7

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10 mM * 1 mL in DMSO USD 55 In-stock
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10 mg USD 50 In-stock
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50 mg USD 100 In-stock
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100 mg USD 140 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Arctigenin purchased from MCE. Usage Cited in: Pharmacol Res. 2020 Feb 22:104721.

    The Western blotting results show that incubating LA795 cells with 100 μM arctigenin led to a decrease in phospho-MEK1/2, phospho-ERK1/2 and cyclin D1 expression (n = 3).
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    Description

    Arctigenin is a lignan found in certain plants of the Asteraceae; it has shown antiviral and anticancer effects in glass; it is the aglycone of arctiin. IC50 value: Target: anticancer agent Arctiin and its aglucone, arctigenin from the fruits of Arctium lappa L. showed potent in vitro antiviral activities against influenza A virus (A/NWS/33, H1N1) (IFV). Based on the data from time-of-addition experiments and on release tests of progeny viruses, arctigenin was assumed to interfere with early event(s) of viral replication after viral penetration into cells, and to suppress the release of progeny viruses from the host cells [1]. arctigenin treatment reduced viability of bladder cancer T24 cells in a dose- and time-dependent manner after treatment with arctigenin (10, 20, 40, 80, and 100 μmol/L) for 24 hr and 48 hr. Arctigenin treatment clearly arrested tumor cells in the G1 phase of the cell cycle. At the molecular level, arctigenin treatment decreased cyclin D1 expression, whereas CDK4 and CDK6 expression levels were unaffected. Moreover, arctigenin selectively altered the phosphorylation of members of the MAPK superfamily, decreasing phosphorylation of ERK1/2 and activated phosphorylation of p38 significantly in a dose-dependent manner [2]. The use of arctigenin has been shown to be effective in a mouse model of Japanese encephalitis [3].

    Clinical Trial
    Molecular Weight

    372.41

    Formula

    C₂₁H₂₄O₆

    CAS No.

    7770-78-7

    SMILES

    O=C1OC[[email protected]](CC2=CC=C(OC)C(OC)=C2)[[email protected]]1CC3=CC=C(O)C(OC)=C3

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 125 mg/mL (335.65 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6852 mL 13.4261 mL 26.8521 mL
    5 mM 0.5370 mL 2.6852 mL 5.3704 mL
    10 mM 0.2685 mL 1.3426 mL 2.6852 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 6.25 mg/mL (16.78 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 6.25 mg/mL (16.78 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 6.25 mg/mL (16.78 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.70%

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    Keywords:

    Arctigenin(-)-ArctigeninMMPInfluenza VirusAutophagyMatrix metalloproteinasesInhibitorinhibitorinhibit

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    Product name:
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    Cat. No.:
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