1388651-30-6
1388651-30-6
Chemical Structure
Elenbecestat
Synonym(s): E2609
- CAS No.: 1388651-30-6
- Formula:C19H18F3N5O2S
- Molecular Weight:437.44
IUPAC Name: N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide
InChIKey: AACUJFVOHGRMTR-DPXNYUHVSA-N
SMILES: FC1=CC=C(NC(C2=NC=C(C(F)F)N=C2)=O)C=C1[C@@]3(N=C(N)SC4)[C@@]4([H])[C@@H](C)OC3
Biological Activity: Elenbecestat (E2609) is a potent, orally bioavailable and BBB-penetrant BACE-1 inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research[1][2].
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Elenbecestat | 99.82% | Elenbecestat (E2609) is a potent, orally bioavailable and BBB-penetrant BACE-1 inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research. | ||||||||||||||||||||
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Elenbecestat (Standard) | ≥98% | Elenbecestat (Standard) is the analytical standard of Elenbecestat (HY-109055). This product is intended for research and analytical applications. Elenbecestat (E2609) is a potent, orally bioavailable and BBB-penetrant BACE-1 inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research. | ||||||||||||||||||||
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References
- [1]. Kumar D, et al.Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead. Eur J Med Chem. 2018 Mar 25;148:436-452. [Content Brief]
- [2]. A single dose of the beta-secretase inhibitor, e2609, decreases CSF bace1 enzymatic activity in cynomolgus monkeys. Alzheimer’s & Dementia, 8(4), P224.
