1. Neuronal Signaling
  2. Beta-secretase

BACE1-IN-1 

Cat. No.: HY-100182
Handling Instructions

BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.

For research use only. We do not sell to patients.

BACE1-IN-1 Chemical Structure

BACE1-IN-1 Chemical Structure

CAS No. : 1310347-50-2

Size Price Stock
1 mg USD 1315 Get quote
5 mg USD 2104 Get quote
10 mg USD 3366 Get quote

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.

IC50 & Target

IC50: 32 nM (human BACE1), 47 nM (human BACE2)[1]

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5685 mL 12.8426 mL 25.6852 mL
5 mM 0.5137 mL 2.5685 mL 5.1370 mL
10 mM 0.2569 mL 1.2843 mL 2.5685 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

389.33

Formula

C₁₈H₁₄F₃N₅O₂

CAS No.

1310347-50-2

SMILES

O=C(C1=NC=C(C#N)C=C1)NC2=CC=C(F)C([[email protected]@]3(C)N=C(N)OCC3(F)F)=C2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
BACE1-IN-1
Cat. No.:
HY-100182
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BACE1-IN-1

Cat. No.: HY-100182