1. Neuronal Signaling
  2. Beta-secretase
  3. NB-360

NB-360 

Cat. No.: HY-124322
Handling Instructions

NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E.

For research use only. We do not sell to patients.

NB-360 Chemical Structure

NB-360 Chemical Structure

CAS No. : 1262857-73-7

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Description

NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E[1][2].

IC50 & Target

IC50: 5 nM (Mouse and human BACE1), 6 nM (BACE2)[1]

Molecular Weight

449.40

Formula

C₂₁H₁₉F₄N₅O₂

CAS No.

1262857-73-7

SMILES

O=C(C1=NC=C(C#N)C=C1C)NC2=CC=C(F)C([[email protected]]3(C)CO[[email protected]](C(F)(F)F)(C)C(N)=N3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NB-360NB360NB 360Beta-secretaseBACEβ-SecretaseInhibitorinhibitorinhibit

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NB-360
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HY-124322
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