1. Cell Cycle/DNA Damage
    Cytoskeleton
    Neuronal Signaling
    Apoptosis
  2. Microtubule/Tubulin
    Beta-secretase
    Apoptosis
  3. Scoulerine

Scoulerine (Synonyms: (-)-Scoulerine; Discretamine)

Cat. No.: HY-N1255
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Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 (ß-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.

For research use only. We do not sell to patients.

Scoulerine Chemical Structure

Scoulerine Chemical Structure

CAS No. : 6451-73-6

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Description

Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 (ß-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells[1].

In Vitro

Scoulerine ((-)-Scoulerine) inhibits mini-panel of human leukemic cells, MOLT-4 (WT), Jurkat (TP53 mutated), Raji (TP53 mutated), HL-60 (TP53 null), U-937 (TP53 mutated), and HEL 92.1.7 (wild-type), with IC50s ranging from 2.7 µM to 6.5 µM[1].
Scoulerine (2.5-20 µM; 24 hours) decreases proliferation of Jurkat and MOLT-4 cells[1].
Scoulerine (2.5-20 µM; 24 hours) induces MOLT-4 and Jurkat cells apoptosis[1].
Scoulerine induces G2 or M cell cycle arrest[1].
Scoulerine (2.5-5 µM; 24 hours) shows an upregulation of p53 protein in p53 wild-type MOLT-4 cells[1].
Scoulerine (2.5-5 µM; 24-48 hours) activates caspase-3/7, -8 and -9 in a dose-dependent manner[1].
Scoulerine (5-10 µM; 24 hours) disrupts microtubule structure of A549 lung carcinoma cells[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Jurkat and MOLT-4 cells
Concentration: 2.5, 5, 10, 15 and 20 µM
Incubation Time: 24 hours
Result: Significantly reduced the viability and proliferation of Jurkat and MOLT-4 cells in a dose dependent manner.

Apoptosis Analysis[1]

Cell Line: MOLT-4 and Jurkat cells
Concentration: 2.5, 5, 10, 15 and 20 µM
Incubation Time: 24 hours
Result: Induced MOLT-4 and Jurkat cells apoptosis.

Cell Cycle Analysis[1]

Cell Line: Jurkat and MOLT-4 leukemic cells
Concentration: 2.5-20 µM
Incubation Time: 16 hours
Result: Induced cell cycle arrest at the G2/M transition.

Western Blot Analysis[1]

Cell Line: MOLT-4 cells
Concentration: 2.5, 5 µM
Incubation Time: 24 hours
Result: Showed an upregulation of p53 protein in p53 wild-type MOLT-4 cells.
Molecular Weight

327.37

Formula

C₁₉H₂₁NO₄

CAS No.

6451-73-6

SMILES

OC1=C(OC)C=C(CCN2CC3=C(O)C(OC)=CC=C3C[[email protected]]24[H])C4=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Scoulerine(-)-Scoulerine DiscretamineMicrotubule/TubulinBeta-secretaseApoptosisBACEβ-Secretase leukemiccellsmicrotubulemitoticdivisionproliferationcyclecancerInhibitorinhibitorinhibit

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