889665-86-5
Chemical Structure
Epiberberine chloride
- CAS 番号: 889665-86-5
- Formula:C20H18ClNO4
- Molecular Weight:371.81
IUPAC Name: 8,9-dimethoxy-11,12-dihydro-[1,3]dioxolo[4,5-h]isoquinolino[2,1-b]isoquinolin-13-ium chloride
InChIKey: DGRBIBRPLDAHJH-UHFFFAOYSA-M
SMILES: COC1=C(OC)C=C2C(CC[N+]3=C2C=C(C=C4)C(C5=C4OCO5)=C3)=C1.[Cl-]
Biological Activity: Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways[2]. Epiberberine has the potential effect in the research of diabetic disease[3].
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Epiberberine chloride | 98.68% | Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways. Epiberberine has the potential effect in the research of diabetic disease. | ||||||||||||||||||||
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Similarity Score 0.98
HY-N0226Epiberberine -
Similarity Score 0.87
HY-N6865Groenlandicine -
Similarity Score 0.82
HY-18258RBerberine chloride (Standard) -
Similarity Score 0.81
HY-17577Berberine chloride hydrate -
Similarity Score 0.81
HY-N0716Berberine -
Similarity Score 0.78
HY-N0736RCoptisine chloride (Standard) -
Similarity Score 0.78
HY-N0110Palmatine chloride -
Similarity Score 0.78
HY-N2373Palmaturbine -
Similarity Score 0.77
HY-125850RBerberrubine chloride (Standard) -
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References
- [1]. Jung HA, et al. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol Pharm Bull. 2009 Aug;32(8):1433-8. [Content Brief]
- [2]. Choi JS, et al. Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways. Arch Pharm Res. 2015 Dec;38(12):2153-62. [Content Brief]
- [3]. Ma H, et al. Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK-Ay Mice. Drug Dev Res. 2016 Jun;77(4):163-70. [Content Brief]
