1194044-20-6
Chemical Structure
LY2811376
- CAS No.: 1194044-20-6
- Formula:C15H14F2N4S
- Molecular Weight:320.36
IUPAC Name: (S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-1,3-thiazinan-2-imine
InChIKey: MJQMRGWYPNIERM-HNNXBMFYSA-N
SMILES: FC1=C(C2=CN=CN=C2)C=C([C@]3(C)CCSC(N3)=N)C(F)=C1
Biological Activity: LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.
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LY2811376 | 99.62% | LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. | ||||||||||||||||||||
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LY2811376 (Standard) | ≥98% | LY2811376 (Standard) is the analytical standard of LY2811376 (HY-10472). This product is intended for research and analytical applications. LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. | ||||||||||||||||||||
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Keywords
