2. Disease Areas
  3. Neurological, Eye or Ear Disease Blood or Cardio-cerebrovascular Disease
  4. Cerebrovascular Disease
  5. Vascular Dementia

Vascular Dementia

Vascular dementia is a form of dementia caused by reduced blood flow to the brain due to strokes or other vascular issues, resulting in impaired oxygen and glucose delivery, neuronal damage, and cognitive decline. It encompasses subtypes such as subcortical vascular dementia, multi-infarct dementia, stroke-related dementia, and mixed dementia, all characterized by cognitive deficits linked to cerebrovascular disease.

Vascular Dementia (2):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N4246
    Bacopaside I 382148-47-2 99.20%
    Bacopaside I is an orally active aquaporin AQP1 inhibitor and PKC modulator with neuroprotective and anticancer activities. Bacopaside I specifically blocks the water channel and cGMP-gated ion channel activities of AQP1 without affecting AQP4, thereby inhibiting the migration of colon cancer cells expressing AQP1. Bacopaside I activates the Akt pathway by interacting with PI3K, specifically inhibits MAO-A, effectively alleviates neuron necrosis and apoptosis induced by oxygen-glucose deprivation, reduces oxidative stress, and regulates the surface expression of neuroreceptors. When combined with Bacopaside II (HY-N6016), Bacopaside I significantly reduces the viability, proliferation and invasion ability of breast cancer cells, and binds to the pregnane X receptor (PXR). Bacopaside I is applicable to the research of colon cancer, breast cancer, vascular dementia, cerebral ischemia and other related diseases.
    Bacopaside I
  • HY-W453397
    Aberrant tau ligand 1 1892461-96-9 99.33%
    Aberrant tau ligand 1 is a tau protein ligand. Aberrant tau ligand 1 engages tau and CRBN to trigger proteasomal degradation. Aberrant tau ligand 1 can be used for synthesis PROTACs, such as QC-01–175 (HY-134850).
    Aberrant tau ligand 1