220961-34-2
Chemical Structure
Methyl isoplatydesmine
- CAS No.: 220961-34-2
- Formula:C17H21NO2
- Molecular Weight:271.35
InChIKey: JUCOOQHXXPUHQO-LLVKDONJSA-N
SMILES: O=C1C2=C(C[C@@H](C2)C(C)(C)OC)N(C3=CC=CC=C31)C
Biological Activity: Methyl isoplatydesmine is a cholinesterase inhibitor with spasmolytic activity, with a Ki value of 30.0 μM against electric eel acetylcholinesterase and a Ki value of 19.0 μM against horse serum butyrylcholinesterase. Methyl isoplatydesmine mediates spasmolytic activity by blocking voltage-dependent calcium channels. Methyl isoplatydesmine can be used in the research of Alzheimer's disease and related dementias[1][2].
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Methyl isoplatydesmine | Methyl isoplatydesmine is a cholinesterase inhibitor with spasmolytic activity, with a Ki value of 30.0 μM against electric eel acetylcholinesterase and a Ki value of 19.0 μM against horse serum butyrylcholinesterase. Methyl isoplatydesmine mediates spasmolytic activity by blocking voltage-dependent calcium channels. Methyl isoplatydesmine can be used in the research of Alzheimer's disease and related dementias. | |||||||||||||||||||||
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- [1]. Atta-ur-Rahman, et al. New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids. Journal of enzyme inhibition and medicinal chemistry. 2006 Dec;21(6):703-10. [Content Brief]
- [2]. Dall'Aqua S. Plant-derived acetylcholinesterase inhibitory alkaloids for the treatment of Alzheimer's disease. Botanics: Targets and Therapy, 2013, 19-28.
Keywords
