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Cat. No.: HY-N21823

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Methyl isoplatydesmine

Methyl isoplatydesmine is a cholinesterase inhibitor with spasmolytic activity, with a K_i value of 30.0 μM against electric eel acetylcholinesterase and a K_i value of 19.0 μM against horse serum butyrylcholinesterase. Methyl isoplatydesmine mediates spasmolytic activity by blocking voltage-dependent calcium channels. Methyl isoplatydesmine can be used in the research of Alzheimer's disease and related dementias.

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CAS No.: 220961-34-2
화학식: C₁₇H₂₁NO₂
분자량:271.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Methyl isoplatydesmine Chemical Structure

CAS No.: 220961-34-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

electric eel AChE

BChE

Calcium Channel

All Cholinesterase (ChE) Isoforms :

AChE
BChE

All Calcium Channel Isoforms :

In Vitro

Methyl isoplatydesmine acts as a linear mixed-type inhibitor of acetylcholinesterase from Torpedo californica, with a K_i of 30 μM; it serves as a non-competitive inhibitor of butyrylcholinesterase from horse serum, with a K_i value of 19 μM^[1].
Methyl isoplatydesmine exhibits dose-dependent spasmolytic activity in spontaneously contracting isolated rabbit jejunum tissues, with an EC₅₀ of 0.1 mg/mL; it shows dose-dependent calcium channel blocking activity in K⁺-depolarized isolated rabbit jejunum tissues, with an EC₅₀ of 0.4 mg/mL^[1].
Methyl isoplatydesmine exhibits significant inhibitory activity against acetylcholinesterase in vitro^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 220961-34-2
분자량 271.35
화학식 C₁₇H₂₁NO₂
SMILES

O=C1C2=C(C[C@@H](C2)C(C)(C)OC)N(C3=CC=CC=C31)C
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Atta-ur-Rahman, et al. New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids. Journal of enzyme inhibition and medicinal chemistry. 2006 Dec;21(6):703-10. [Content Brief]

[2]. Dall'Aqua S. Plant-derived acetylcholinesterase inhibitory alkaloids for the treatment of Alzheimer's disease. Botanics: Targets and Therapy, 2013, 19-28.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Methyl isoplatydesmine

All Cholinesterase (ChE) Isoforms

All Calcium Channel Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Methyl isoplatydesmine Related Classifications

HY-N21823 Related Classifications