Methyl isoplatydesmine
Methyl isoplatydesmine is a cholinesterase inhibitor with spasmolytic activity, with a Ki value of 30.0 μM against electric eel acetylcholinesterase and a Ki value of 19.0 μM against horse serum butyrylcholinesterase. Methyl isoplatydesmine mediates spasmolytic activity by blocking voltage-dependent calcium channels. Methyl isoplatydesmine can be used in the research of Alzheimer's disease and related dementias.
For research use only. We do not sell to patients.
- CAS No.: 220961-34-2
- Formula: C17H21NO2
- Molecular Weight:271.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Calcium Channel Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
electric eel AChE |
BChE |
Calcium Channel |
In Vitro
Methyl isoplatydesmine acts as a linear mixed-type inhibitor of acetylcholinesterase from Torpedo californica, with a Ki of 30 μM; it serves as a non-competitive inhibitor of butyrylcholinesterase from horse serum, with a Ki value of 19 μM[1].
Methyl isoplatydesmine exhibits dose-dependent spasmolytic activity in spontaneously contracting isolated rabbit jejunum tissues, with an EC50 of 0.1 mg/mL; it shows dose-dependent calcium channel blocking activity in K+-depolarized isolated rabbit jejunum tissues, with an EC50 of 0.4 mg/mL[1].
Methyl isoplatydesmine exhibits significant inhibitory activity against acetylcholinesterase in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 220961-34-2
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Molecular Weight 271.35
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Formula C17H21NO2
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SMILES
O=C1C2=C(C[C@@H](C2)C(C)(C)OC)N(C3=CC=CC=C31)C
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Methyl isoplatydesmine Related Classifications
HY-N21823 Related Classifications
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