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Art. -Nr.: HY-N21823

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Methyl isoplatydesmine

Methyl isoplatydesmine is a cholinesterase inhibitor with spasmolytic activity, with a K_i value of 30.0 μM against electric eel acetylcholinesterase and a K_i value of 19.0 μM against horse serum butyrylcholinesterase. Methyl isoplatydesmine mediates spasmolytic activity by blocking voltage-dependent calcium channels. Methyl isoplatydesmine can be used in the research of Alzheimer's disease and related dementias.

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CAS. Nr.: 220961-34-2
Formel: C₁₇H₂₁NO₂
Molecular Weight:271.35

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Methyl isoplatydesmine Chemical Structure

CAS. Nr.: 220961-34-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

electric eel AChE

BChE

Calcium Channel

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen :

AChE
BChE

Alle Calcium Channel Isoform-spezifische Produkte anzeigen :

In Vitro

Methyl isoplatydesmine acts as a linear mixed-type inhibitor of acetylcholinesterase from Torpedo californica, with a K_i of 30 μM; it serves as a non-competitive inhibitor of butyrylcholinesterase from horse serum, with a K_i value of 19 μM^[1].
Methyl isoplatydesmine exhibits dose-dependent spasmolytic activity in spontaneously contracting isolated rabbit jejunum tissues, with an EC₅₀ of 0.1 mg/mL; it shows dose-dependent calcium channel blocking activity in K⁺-depolarized isolated rabbit jejunum tissues, with an EC₅₀ of 0.4 mg/mL^[1].
Methyl isoplatydesmine exhibits significant inhibitory activity against acetylcholinesterase in vitro^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

Chemical Information

CAS. Nr. 220961-34-2
Molecular Weight 271.35
Formel C₁₇H₂₁NO₂
SMILES

O=C1C2=C(C[C@@H](C2)C(C)(C)OC)N(C3=CC=CC=C31)C
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Atta-ur-Rahman, et al. New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids. Journal of enzyme inhibition and medicinal chemistry. 2006 Dec;21(6):703-10. [Content Brief]

[2]. Dall'Aqua S. Plant-derived acetylcholinesterase inhibitory alkaloids for the treatment of Alzheimer's disease. Botanics: Targets and Therapy, 2013, 19-28.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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