country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-N21823

Copy Link Print Information

Methyl isoplatydesmine

Methyl isoplatydesmine is a cholinesterase inhibitor with spasmolytic activity, with a K_i value of 30.0 μM against electric eel acetylcholinesterase and a K_i value of 19.0 μM against horse serum butyrylcholinesterase. Methyl isoplatydesmine mediates spasmolytic activity by blocking voltage-dependent calcium channels. Methyl isoplatydesmine can be used in the research of Alzheimer's disease and related dementias.

For research use only. We do not sell to patients.

CAS No.: 220961-34-2
Formula: C₁₇H₂₁NO₂
Molecular Weight:271.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Methyl isoplatydesmine Chemical Structure

CAS No.: 220961-34-2

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

electric eel AChE

BChE

Calcium Channel

All Cholinesterase (ChE) Isoforms :

AChE
BChE

All Calcium Channel Isoforms :

In Vitro

Methyl isoplatydesmine acts as a linear mixed-type inhibitor of acetylcholinesterase from Torpedo californica, with a K_i of 30 μM; it serves as a non-competitive inhibitor of butyrylcholinesterase from horse serum, with a K_i value of 19 μM^[1].
Methyl isoplatydesmine exhibits dose-dependent spasmolytic activity in spontaneously contracting isolated rabbit jejunum tissues, with an EC₅₀ of 0.1 mg/mL; it shows dose-dependent calcium channel blocking activity in K⁺-depolarized isolated rabbit jejunum tissues, with an EC₅₀ of 0.4 mg/mL^[1].
Methyl isoplatydesmine exhibits significant inhibitory activity against acetylcholinesterase in vitro^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 220961-34-2
Molecular Weight 271.35
Formula C₁₇H₂₁NO₂
SMILES

O=C1C2=C(C[C@@H](C2)C(C)(C)OC)N(C3=CC=CC=C31)C
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Atta-ur-Rahman, et al. New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids. Journal of enzyme inhibition and medicinal chemistry. 2006 Dec;21(6):703-10. [Content Brief]

[2]. Dall'Aqua S. Plant-derived acetylcholinesterase inhibitory alkaloids for the treatment of Alzheimer's disease. Botanics: Targets and Therapy, 2013, 19-28.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote