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製品番号: HY-N21823

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Methyl isoplatydesmine

Methyl isoplatydesmine is a cholinesterase inhibitor with spasmolytic activity, with a K_i value of 30.0 μM against electric eel acetylcholinesterase and a K_i value of 19.0 μM against horse serum butyrylcholinesterase. Methyl isoplatydesmine mediates spasmolytic activity by blocking voltage-dependent calcium channels. Methyl isoplatydesmine can be used in the research of Alzheimer's disease and related dementias.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 220961-34-2
分子式: C₁₇H₂₁NO₂
分子量:271.35

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Methyl isoplatydesmine 構造式

CAS 番号: 220961-34-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

electric eel AChE

BChE

Calcium Channel

Cholinesterase (ChE) アイソフォーム固有の製品をすべて表示 :

AChE
BChE

Calcium Channel アイソフォーム固有の製品をすべて表示 :

体外実験

Methyl isoplatydesmine acts as a linear mixed-type inhibitor of acetylcholinesterase from Torpedo californica, with a K_i of 30 μM; it serves as a non-competitive inhibitor of butyrylcholinesterase from horse serum, with a K_i value of 19 μM^[1].
Methyl isoplatydesmine exhibits dose-dependent spasmolytic activity in spontaneously contracting isolated rabbit jejunum tissues, with an EC₅₀ of 0.1 mg/mL; it shows dose-dependent calcium channel blocking activity in K⁺-depolarized isolated rabbit jejunum tissues, with an EC₅₀ of 0.4 mg/mL^[1].
Methyl isoplatydesmine exhibits significant inhibitory activity against acetylcholinesterase in vitro^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

化学情報

CAS 番号 220961-34-2
分子量 271.35
分子式 C₁₇H₂₁NO₂
SMILES

O=C1C2=C(C[C@@H](C2)C(C)(C)OC)N(C3=CC=CC=C31)C
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Atta-ur-Rahman, et al. New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids. Journal of enzyme inhibition and medicinal chemistry. 2006 Dec;21(6):703-10. [Content Brief]

[2]. Dall'Aqua S. Plant-derived acetylcholinesterase inhibitory alkaloids for the treatment of Alzheimer's disease. Botanics: Targets and Therapy, 2013, 19-28.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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