2. NF-κB
    Immunology/Inflammation
  3. NF-κB
    COX
    PGE synthase
    NO Synthase
  4. Dehydroevodiamine

Dehydroevodiamine 

Cat. No.: HY-N2106
Handling Instructions

Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.

For research use only. We do not sell to patients.

Dehydroevodiamine Chemical Structure

Dehydroevodiamine Chemical Structure

CAS No. : 67909-49-3

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  • Biological Activity

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  • References

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Description

Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes[1]. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells[2].

IC50 & Target

iNOS

 

In Vitro

Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages[2].
Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS-induced increase in the iNOS and COX-2 mRNA expression[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: RAW 264.7 macrophage cells
Concentration: 10 μM, 30 μM, 50 μM
Incubation Time: pretreated 2 hours
Result: Reduced iNOS and COX-2 expression and increased IκB-α expression.

RT-PCR[2]

Cell Line: RAW 264.7 macrophage cells
Concentration: 10 μM, 30 μM, 50 μM
Incubation Time: pretreated 2 hours
Result: Reduced iNOS and COX-2 mRNA expression.
Molecular Weight

301.34

Formula

C19H15N3O
CAS No.
SMILES

O=C1N2C(C([N-]C3=C4C=CC=C3)=C4CC2)=[N+](C)C5=C1C=CC=C5
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (27.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3185 mL 16.5926 mL 33.1851 mL
5 mM 0.6637 mL 3.3185 mL 6.6370 mL
10 mM 0.3319 mL 1.6593 mL 3.3185 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Dehydroevodiamine67909-49-3NF-κBCOXPGE synthaseNO SynthaseNuclear factor-κBNuclear factor-kappaBCyclooxygenaseProstaglandin E synthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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