1. NF-κB
    Immunology/Inflammation
  2. NF-κB
    COX
    PGE synthase
    NO Synthase
  3. Dehydroevodiamine

Dehydroevodiamine 

Cat. No.: HY-N2106
Handling Instructions

Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.

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Dehydroevodiamine Chemical Structure

Dehydroevodiamine Chemical Structure

CAS No. : 67909-49-3

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Description

Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes[1]. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells[2].

IC50 & Target

iNOS; COX-2; PGE2; NF-κB[2]

In Vitro

Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages[2].
Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS-induced increase in the iNOS and COX-2 mRNA expression[2].

Western Blot Analysis[2]

Cell Line: RAW 264.7 macrophage cells
Concentration: 10 μM, 30 μM, 50 μM
Incubation Time: pretreated 2 hours
Result: Reduced iNOS and COX-2 expression and increased IκB-α expression.

RT-PCR[2]

Cell Line: RAW 264.7 macrophage cells
Concentration: 10 μM, 30 μM, 50 μM
Incubation Time: pretreated 2 hours
Result: Reduced iNOS and COX-2 mRNA expression.
Molecular Weight

301.34

Formula

C₁₉H₁₅N₃O

CAS No.

67909-49-3

SMILES

O=C1N2C(C([N-]C3=C4C=CC=C3)=C4CC2)=[N+](C)C5=C1C=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DehydroevodiamineNF-κBCOXPGE synthaseNO SynthaseNuclear factor-κBNuclear factor-kappaBCyclooxygenaseProstaglandin E synthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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Dehydroevodiamine
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