Increased feline cerebral blood flow induced by dehydroevodiamine hydrochloride from Evodia rutaecarpa

  • J Nat Prod. 1994 Mar;57(3):387-9. doi: 10.1021/np50105a009.
A Haji  1 ,  Y Momose ,  R Takeda ,  S Nakanishi ,  T Horiuchi ,  M Arisawa
Affiliations
  • 1. Department of Pharmacology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
PMID: 8201313 DOI: 10.1021/np50105a009
Abstract

Dehydroevodiamine hydrochloride (0.1-0.3 mg/kg iv), which was isolated from the leaves of Evodia rutaecarpa, increased the cerebral blood flow recorded from the surface of the supra-sylvian gyrus in anesthetized cats. This action reached a maximum 1-4 min after injection and continued for 10 min. However, the compound had negligible effects on Other cardiorespiratory functions at the doses examined. These results suggest that the compound selectively increases cerebral blood flow.

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