1. NF-κB
    Autophagy
  2. Keap1-Nrf2
    Autophagy
  3. Ezetimibe ketone

Ezetimibe ketone (Synonyms: EZM-K)

Cat. No.: HY-133114
Handling Instructions

Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor.

For research use only. We do not sell to patients.

Ezetimibe ketone Chemical Structure

Ezetimibe ketone Chemical Structure

CAS No. : 191330-56-0

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Description

Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor[1][2][3].

IC50 & Target

NPC1L1, Nrf2[1]

Molecular Weight

407.41

Formula

C₂₄H₁₉F₂NO₃

CAS No.

191330-56-0

SMILES

O=C1N(C2=CC=C(F)C=C2)[[email protected]](C3=CC=C(O)C=C3)[[email protected]]1CCC(C4=CC=C(F)C=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Ezetimibe ketoneEZM-KKeap1-Nrf2AutophagyMetaboliteNPC1L1 Ezetimibe Nrf2Inhibitorinhibitorinhibit

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