Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase
- Arch Pharm Res. 2002 Dec;25(6):817-9. doi: 10.1007/BF02976997.
Affiliations
- 1. College of Pharmacy, Woosuk University, Samrye 565-701, Korea. [email protected]
PMID: 12510831
DOI: 10.1007/BF02976997
Abstract
In the course of screening Korean natural products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) showed significant inhibitory effects on AChE. Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the IC50 value of corynoline was 30.6 microM. The AChE inhibitory activity of corynoline was reversible and noncompetitive.
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