2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Obidoxime dichloride

Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated.

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Obidoxime dichloride Chemical Structure

Obidoxime dichloride Chemical Structure

CAS No. : 114-90-9

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Obidoxime dichloride Related Antibodies

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Description

Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated[1].

In Vivo

Obidoxime dichloride (intramuscular injection; 10 mg/kg; after 60 mins) exhibits a LD50 of 57.7 mg/kg after administration of sarin, and it reduces reduces acute toxicity of sarin was evaluated[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NMRI male mice
Dosage: 10 mg/kg
Administration: Intramuscular injection
Result: Was effective in reactivating sarin-inhibited acetylcholinesterase (AChE).
Molecular Weight

359.21

Formula

C14H16Cl2N4O3
CAS No.
SMILES

O/N=C/C1=CC=[N+](C=C1)COC[N+]2=CC=C(C=C2)/C=N/O.[Cl-].[Cl-]
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Obidoxime dichloride Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Obidoxime dichloride114-90-9Cholinesterase (ChE)acutetoxicityacetylcholinesterasesarinInhibitorinhibitorinhibit

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