sEH/AChE-IN-4
sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively.
For research use only. We do not sell to patients.
- CAS No.: 2490589-12-1
- Formula: C35H39ClF3N5O3
- Molecular Weight:670.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 3.1 nM (hsEH), 1660 ± 450 nM (hAChE), 179 ± 26 nM (hBChE), 14.5 nM (msEH), 102 ± 18 nM (mAChE)[1]
Chemical Information
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CAS No. 2490589-12-1
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Molecular Weight 670.16
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Formula C35H39ClF3N5O3
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SMILES
O=C(N1CCC(CC1)NC(NC2=CC=C(C=C2)OC(F)(F)F)=O)CCCCNC3=C4C(C[C@H]5C[C@@H]4CC(C)=C5)=NC6=CC(Cl)=CC=C63
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
sEH/AChE-IN-4 Related Classifications
HY-145833A Related Classifications
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